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Rabbit Anti-GPR107 Recombinant Antibody (EG1358) (CBMAB-EN1637-LY)

The product is antibody recognizes GPR107. The antibody EG1358 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all GPR107 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1358
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR107.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 107
Entrez Gene ID
57720
UniProt ID
Q5VW38
Alternative Names
GCDRP; LUSTR1; bA138E2.2
Function
Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024).

Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).

(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.
Biological Process
Clathrin-dependent endocytosis Source: GO_Central
Cellular Location
Trans-Golgi network membrane; Cell membrane
Topology
Extracellular: 40-263
Helical: 264-284
Cytoplasmic: 285-293
Helical: 294-314
Extracellular: 315-337
Helical: 338-358
Cytoplasmic: 359-368
Helical: 369-389
Extracellular: 390-402
Helical: 403-423
Cytoplasmic: 424-498
Helical: 499-519
Extracellular: 520-524
Helical: 525-544
Cytoplasmic: 545-600
PTM
Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.

Garcia-Estrada, A., Herman-Sanchez, N., Lopez-Canovas, J. L., Saez-Martinez, P., Zamora-Olaya, J. M., Rodriguez-Peralvarez, M., ... & Gahete, M. D. (2023, May). Neuronostatin receptor GPR107 as a potential biomarker and therapeutic target in chronic liver disease. In Endocrine Abstracts (Vol. 90). Bioscientifica.

Calderón-Zamora, L., Canizalez-Román, A., León-Sicairos, N., Aguilera-Mendez, A., Huang, F., Hong, E., & Villafaña, S. (2021). Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats. Journal of Receptors and Signal Transduction, 41(6), 558-565.

Sáez-Martínez, P., Jiménez-Vacas, J. M., León-González, A. J., Herrero-Aguayo, V., Montero Hidalgo, A. J., Gómez-Gómez, E., ... & Luque, R. M. (2020). Unleashing the diagnostic, prognostic and therapeutic potential of the neuronostatin/GPR107 system in prostate cancer. Journal of Clinical Medicine, 9(6), 1703.

Grote, S., Mahmood, A., Samson, W., & Yosten, G. (2020). A New Player in Glucose Counterregulation: the Glycemic Effects of Neuronostatin through GPR107 and Enhanced Glucagon Secretion. The FASEB Journal, 34(S1), 1-1.

Saez-Martinez, P., Jimenez-Vacas, J. M., Herrero-Aguayo, V., Leon-Gonzalez, A. J., Gomez-Gomez, E., Montero-Hidalgo, A. J., ... & Luque, R. M. (2019, May). Neuronostatin and GPR107 system: a novel therapeutic circuit in prostate cancer. In Endocrine Abstracts (Vol. 63). Bioscientifica.

Huang, G., Jiang, H., Lin, Y., Xia, W., Luo, Y., Wu, Y., ... & Jiang, X. (2018). LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner. Journal of Experimental & Clinical Cancer Research, 37, 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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