GPR84

GPR84 was activated by MCFAs with the hydroxyl group at the 2- or 3- position more effectively than non-hydroxylated MCFAs.

G protein-coupled receptor 84

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.

Neuropeptide signaling pathway Source: GO_Central

Cell membrane

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-57
Helical: 58-78
Extracellular: 79-94
Helical: 95-115
Cytoplasmic: 116-144
Helical: 145-165
Extracellular: 166-180
Helical: 181-201
Cytoplasmic: 202-320
Helical: 321-341
Extracellular: 342-352
Helical: 353-373
Cytoplasmic: 374-396