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Mouse Anti-GPR84 Recombinant Antibody (CBLG1-1648) (CBMAB-G4676-LY)

This product is antibody recognizes GPR84. The antibody CBLG1-1648 immunoassay techniques such as: ELISA, WB.
See all GPR84 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1648
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 84
Entrez Gene ID
53831
UniProt ID
Q9NQS5
Alternative Names
EX33; GPCR4
Function
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
Biological Process
Neuropeptide signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-57
Helical: 58-78
Extracellular: 79-94
Helical: 95-115
Cytoplasmic: 116-144
Helical: 145-165
Extracellular: 166-180
Helical: 181-201
Cytoplasmic: 202-320
Helical: 321-341
Extracellular: 342-352
Helical: 353-373
Cytoplasmic: 374-396

Li, X., Yuan, C., Yang, B., Pang, H., Li, W., Li, M., ... & Zhang, J. (2023). Caprylic Acid (FFA C8: 0) promotes the progression of prostate cancer by up-regulating G protein-coupled receptor 84/Krüppel-like factor 7. BMC cancer, 23(1), 1-14.

Mahindra, A., Jenkins, L., Marsango, S., Huggett, M., Huggett, M., Robinson, L., ... & Jamieson, A. G. (2022). Investigating the Structure–Activity Relationship of 1, 2, 4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. Journal of Medicinal Chemistry, 65(16), 11270-11290.

Peters, A., Rabe, P., Liebing, A. D., Krumbholz, P., Nordström, A., Jäger, E., ... & Stäubert, C. (2022). Hydroxycarboxylic acid receptor 3 and GPR84–Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. Pharmacological Research, 176, 106047.

Velasco, C., Conde-Sieira, M., Comesaña, S., Chivite, M., Míguez, J. M., & Soengas, J. L. (2021). Role of the G protein-coupled receptors GPR84 and GPR119 in the central regulation of food intake in rainbow trout. Journal of Experimental Biology, 224(13), jeb242360.

Puengel, T., De Vos, S., Hundertmark, J., Kohlhepp, M., Guldiken, N., Pujuguet, P., ... & Tacke, F. (2020). The medium-chain fatty acid receptor GPR84 mediates myeloid cell infiltration promoting steatohepatitis and fibrosis. Journal of Clinical Medicine, 9(4), 1140.

Chen, L. H., Zhang, Q., Xie, X., & Nan, F. J. (2020). Modulation of the G-protein-coupled receptor 84 (GPR84) by agonists and antagonists. Journal of Medicinal Chemistry, 63(24), 15399-15409.

Peters, A., Rabe, P., Krumbholz, P., Kalwa, H., Kraft, R., Schöneberg, T., & Stäubert, C. (2020). Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84. Cell Communication and Signaling, 18(1), 1-19.

Köse, M., Pillaiyar, T., Namasivayam, V., De Filippo, E., Sylvester, K., Ulven, T., ... & Müller, C. E. (2019). An agonist radioligand for the proinflammatory lipid-activated G protein-coupled receptor GPR84 providing structural insights. Journal of medicinal chemistry, 63(5), 2391-2410.

Park, J. W., Yoon, H. J., Kang, W. Y., Cho, S., Seong, S. J., Lee, H. W., ... & Kim, H. J. (2018). G protein‐coupled receptor 84 controls osteoclastogenesis through inhibition of NF‐κB and MAPK signaling pathways. Journal of Cellular Physiology, 233(2), 1481-1489.

Pillaiyar, T., Köse, M., Namasivayam, V., Sylvester, K., Borges, G., Thimm, D., ... & Müller, C. E. (2018). 6-(Ar) Alkylamino-substituted uracil derivatives: lipid mimetics with potent activity at the orphan G Protein-Coupled Receptor 84 (GPR84). ACS omega, 3(3), 3365-3383.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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