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GRIA1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Glutamate Ionotropic Receptor AMPA Type Subunit 1
Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Biological Process
Cellular response to ammonium ion Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Long-term memory Source: Ensembl
Long-term synaptic depression Source: Ensembl
Receptor internalization Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cell membrane; Postsynaptic cell membrane; Postsynaptic density membrane; Endoplasmic reticulum membrane; Early endosome membrane; Recycling endosome membrane; Dendrite; Dendritic spine. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).
Topology
Extracellular: 19-536
Helical: 537-557
Cytoplasmic: 558-584
Helical: 585-600
Extracellular: 601-603
Helical: 604-609
Cytoplasmic: 610-630
Helical: 631-805
Extracellular: 806-826
Helical: 827-906
PTM
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).
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Anti-GRIA1 antibodies

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Mouse Anti-GRIA1 Recombinant Antibody (CAP856) (CBMAB-AP2605LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP856
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (CBMAB-AO528LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-GRIA1 Recombinant Antibody (RM296) (CBMAB-BR192LY)

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Target: GRIA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM296
Application*: IHC, WB
Datasheet SDS

Rabbit Anti-GRIA1 (Phosphorylated S863) Recombinant Antibody (D10G5) (PTM-CBMAB-0557LY)

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Target: GRIA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D10G5
Application*: WB, IP
Datasheet SDS

Mouse Anti-GRIA1 (N-terminus) Recombinant Antibody (CBFYH-3476) (CBMAB-H4024-FY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBFYH-3476
Application*: WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (CBFYH-3338) (CBMAB-H0286-FY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYH-3338
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (CBLG1-1732) (CBMAB-G4882-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-1732
Application*: WB
Datasheet SDS

Rabbit Anti-GRIA1 Recombinant Antibody (CBLG1-1729) (CBMAB-G4879-LY)

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Target: GRIA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog
Clone: CBLG1-1729
Application*: WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (CBLG1-1733) (CBMAB-G4883-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1733
Application*: IF, IP, WB
Datasheet SDS

Rabbit Anti-GRIA1 Recombinant Antibody (CBLG1-1730) (CBMAB-G4880-LY)

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Target: GRIA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-1730
Application*: WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (CBLG1-1728) (CBMAB-G4878-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBLG1-1728
Application*: E, WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (RH95) (CBMAB-G4875-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse
Clone: RH95
Application*: WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (1G10) (CBMAB-G4869-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G10
Application*: E, WB
Datasheet SDS

Mouse Anti-GRIA1 Recombinant Antibody (S355-1) (CBMAB-G0771-LY)

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Target: GRIA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: S355-1
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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