GRK6

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Full Name
G protein-coupled receptor kinase 6
Biological Process
G protein-coupled receptor signaling pathway Source: Reactome
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Membrane
PTM
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
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Anti-GRK6 antibodies

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Target: GRK6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 4
Application*: WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1788
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8D9
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8D4
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8B7
Application*: E, IP, IF, WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2G1
Application*: E, IP, WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYH-0490
Application*: E, IF, WB
Target: GRK6
Sensitivity: 0.034 ng/mL
Detection Range: 0.07-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Grk6
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: GRK6
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-589
Tag: GST Tag
Target: GRK6
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Target: GRK6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1447
Application*: WB
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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