GRK6
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Full Name
G protein-coupled receptor kinase 6
Biological Process
G protein-coupled receptor signaling pathway Source: Reactome
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Membrane
PTM
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
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Anti-GRK6 antibodies
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Target: GRK6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 4
Application*: WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1788
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8D9
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8D4
Application*: WB, E
Target: GRK6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8B7
Application*: E, IP, IF, WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2G1
Application*: E, IP, WB
Target: GRK6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYH-0490
Application*: E, IF, WB
Target: GRK6
Sensitivity: 0.034 ng/mL
Detection Range: 0.07-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Grk6
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: GRK6
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-589
Tag: GST Tag
Target: GRK6
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Target: GRK6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1447
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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