Rat Grk6 ELISA Kit (V2LY-0626-LY2219)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0097 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
66.0 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
G protein-coupled receptor kinase 6
Biological Process
G protein-coupled receptor signaling pathway Source: Reactome
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Membrane
PTM
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.

Varney, M. J., Steyaert, W., Coucke, P. J., Delanghe, J. R., Uehling, D. E., Joseph, B., ... & Benovic, J. L. (2022). G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. Journal of Biological Chemistry, 298(10).

Uehling, D. E., Joseph, B., Chung, K. C., Zhang, A. X., Ler, S., Prakesch, M. A., ... & Tiedemann, R. E. (2021). Design, synthesis, and characterization of 4-aminoquinazolines as potent inhibitors of the G protein-coupled receptor kinase 6 (GRK6) for the treatment of multiple myeloma. Journal of medicinal chemistry, 64(15), 11129-11147.

Olson, T. L., Zhang, S., Labban, D., Kaschner, E., Aceves, M., Iyer, S., ... & Fromme, P. (2021). Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma. Protein Expression and Purification, 185, 105890.

Stegen, M., Engler, A., Ochsenfarth, C., Manthey, I., Peters, J., Siffert, W., & Frey, U. H. (2021). Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. Plos one, 16(2), e0247087.

Chaudhary, P. K., Kim, S., Jee, Y., Lee, S. H., Park, K. M., & Kim, S. (2020). Role of GRK6 in the regulation of platelet activation through selective G protein-coupled receptor (GPCR) desensitization. International Journal of Molecular Sciences, 21(11), 3932.

Wu, W., Sung, C. C., Yu, P., Li, J., & Chung, K. K. (2020). S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease. PLoS One, 15(4), e0232019.

Yao, S., Wu, D., Chen, J., Wang, P., Lv, X., & Huang, J. (2019). Hypermethylation of the G protein‐coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. FEBS Open Bio, 9(4), 605-617.

Che, X., Zhang, G., Zhang, X., & Xue, J. (2018). Overexpression of G protein-coupled receptor kinase 6 (GRK6) is associated with progression and poor prognosis of papillary thyroid carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 3540.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human GRK6 ELISA Kit (CAT#: V2LY-0626-LY4602)

Human Recombinant GRK6, Active protein, GST Tag (CAT#: V2LY-0526-LY4420)

Human Recombinant GRK6 protein, GST Tag (CAT#: V2LY-0526-LY4421)

Related Products

Mouse Anti-GRK6 Recombinant Antibody (2G1) (CAT#: CBMAB-G5014-LY)

Mouse Anti-GRK6 Recombinant Antibody (CBFYH-0490) (CAT#: CBMAB-H1359-FY)

Rabbit Anti-GRK6 Recombinant Antibody (EG1447) (CAT#: CBMAB-EN1728-LY)

Rabbit Anti-GRK6 Recombinant Antibody (4) (CAT#: CBMAB-G5019-LY)

Human Recombinant GRK6 protein, GST Tag (CAT#: V2LY-0526-LY4421)

Mouse Anti-GRK6 Recombinant Antibody (8D4) (CAT#: CBMAB-G5017-LY)

Human GRK6 ELISA Kit (CAT#: V2LY-0626-LY4602)

Mouse Anti-GRK6 Recombinant Antibody (CBLG1-1788) (CAT#: CBMAB-G5022-LY)

Mouse Anti-GRK6 Recombinant Antibody (8D9) (CAT#: CBMAB-G5018-LY)

Mouse Anti-GRK6 Recombinant Antibody (8B7) (CAT#: CBMAB-G5016-LY)

Isotype control

For research use only. Not intended for any clinical use.

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