Human Recombinant GRK6, Active protein, GST Tag (V2LY-0526-LY4420)

Name: Human Recombinant GRK6, Active protein, GST Tag
SKU: V2LY-0526-LY4420
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant GRK6, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 93 kDa.

Molecule Mass

93 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor kinase 6

Biological Process

G protein-coupled receptor signaling pathway Source: Reactome
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Membrane

PTM

It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.

Varney, M. J., Steyaert, W., Coucke, P. J., Delanghe, J. R., Uehling, D. E., Joseph, B., ... & Benovic, J. L. (2022). G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. Journal of Biological Chemistry, 298(10).

Uehling, D. E., Joseph, B., Chung, K. C., Zhang, A. X., Ler, S., Prakesch, M. A., ... & Tiedemann, R. E. (2021). Design, synthesis, and characterization of 4-aminoquinazolines as potent inhibitors of the G protein-coupled receptor kinase 6 (GRK6) for the treatment of multiple myeloma. Journal of medicinal chemistry, 64(15), 11129-11147.

Olson, T. L., Zhang, S., Labban, D., Kaschner, E., Aceves, M., Iyer, S., ... & Fromme, P. (2021). Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma. Protein Expression and Purification, 185, 105890.

Stegen, M., Engler, A., Ochsenfarth, C., Manthey, I., Peters, J., Siffert, W., & Frey, U. H. (2021). Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. Plos one, 16(2), e0247087.

Chaudhary, P. K., Kim, S., Jee, Y., Lee, S. H., Park, K. M., & Kim, S. (2020). Role of GRK6 in the regulation of platelet activation through selective G protein-coupled receptor (GPCR) desensitization. International Journal of Molecular Sciences, 21(11), 3932.

Wu, W., Sung, C. C., Yu, P., Li, J., & Chung, K. K. (2020). S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease. PLoS One, 15(4), e0232019.

Yao, S., Wu, D., Chen, J., Wang, P., Lv, X., & Huang, J. (2019). Hypermethylation of the G protein‐coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. FEBS Open Bio, 9(4), 605-617.

Che, X., Zhang, G., Zhang, X., & Xue, J. (2018). Overexpression of G protein-coupled receptor kinase 6 (GRK6) is associated with progression and poor prognosis of papillary thyroid carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 24, 3540.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Grk6 ELISA Kit (CAT#: V2LY-0626-LY2219)

Human GRK6 ELISA Kit (CAT#: V2LY-0626-LY4602)

Human Recombinant GRK6 protein, GST Tag (CAT#: V2LY-0526-LY4421)

Related Products

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Mouse Anti-GRK6 Recombinant Antibody (CBFYH-0490) (CAT#: CBMAB-H1359-FY)

Rat Grk6 ELISA Kit (CAT#: V2LY-0626-LY2219)

Human Recombinant GRK6 protein, GST Tag (CAT#: V2LY-0526-LY4421)

Human GRK6 ELISA Kit (CAT#: V2LY-0626-LY4602)

Mouse Anti-GRK6 Recombinant Antibody (8D9) (CAT#: CBMAB-G5018-LY)

Mouse Anti-GRK6 Recombinant Antibody (CBLG1-1788) (CAT#: CBMAB-G5022-LY)

Mouse Anti-GRK6 Recombinant Antibody (8B7) (CAT#: CBMAB-G5016-LY)

Mouse Anti-GRK6 Recombinant Antibody (2G1) (CAT#: CBMAB-G5014-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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