HDAC2

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Histone Deacetylase 2

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810).

Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).

Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404).

Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity).

Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227).

May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity).

Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678).

In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674).

Behavioral response to ethanol Source: Ensembl
Cardiac muscle hypertrophy Source: Ensembl
Cellular response to dopamine Source: Ensembl
Cellular response to heat Source: Ensembl
Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Cellular response to transforming growth factor beta stimulus Source: Ensembl
Chromatin remodeling Source: ComplexPortal
Circadian regulation of gene expression Source: UniProtKB
Dendrite development Source: UniProtKB
Embryonic digit morphogenesis Source: BHF-UCL
Epidermal cell differentiation Source: BHF-UCL
Eyelid development in camera-type eye Source: BHF-UCL
Fungiform papilla formation Source: BHF-UCL
Hair follicle placode formation Source: BHF-UCL
Heterochromatin organization Source: BHF-UCL
Histone deacetylation Source: ComplexPortal
Histone H3 deacetylation Source: UniProtKB
Histone H4 deacetylation Source: UniProtKB
Negative regulation of apoptotic process Source: BHF-UCL
Negative regulation of dendritic spine development Source: Ensembl
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of MHC class II biosynthetic process Source: BHF-UCL
Negative regulation of neuron projection development Source: BHF-UCL
Negative regulation of peptidyl-lysine acetylation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Odontogenesis of dentin-containing tooth Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: Ensembl
Positive regulation of interleukin-1 production Source: Ensembl
Positive regulation of male mating behavior Source: Ensembl
Positive regulation of oligodendrocyte differentiation Source: Ensembl
Positive regulation of proteolysis Source: BHF-UCL
Positive regulation of signaling receptor activity Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: Ensembl
Positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
Response to amphetamine Source: Ensembl
Response to caffeine Source: Ensembl
Response to cocaine Source: Ensembl
Response to hyperoxia Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to nicotine Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl

Cytoplasm; Nucleus

S-nitrosylated by GAPDH. In neurons, S-nitrosylation at Cys-262 and Cys-274 does not affect enzyme activity, but induces HDAC2 release from chromatin. This in turn increases acetylation of histones surrounding neurotrophin-dependent gene promoters and promotes their transcription. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.