HGS
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Biological Process
Endosomal transport Source: UniProtKB
Macroautophagy Source: ParkinsonsUK-UCL
Membrane invagination Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of receptor signaling pathway via JAK-STAT Source: HGNC-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of exosomal secretion Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein localization to membrane Source: UniProtKB
Protein targeting to lysosome Source: UniProtKB
Regulation of MAP kinase activity Source: UniProtKB
Regulation of protein catabolic process Source: HGNC-UCL
Signal transduction Source: ProtInc
Macroautophagy Source: ParkinsonsUK-UCL
Membrane invagination Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of receptor signaling pathway via JAK-STAT Source: HGNC-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of exosomal secretion Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein localization to membrane Source: UniProtKB
Protein targeting to lysosome Source: UniProtKB
Regulation of MAP kinase activity Source: UniProtKB
Regulation of protein catabolic process Source: HGNC-UCL
Signal transduction Source: ProtInc
Cellular Location
Early endosome membrane; Multivesicular body membrane; Cytoplasm. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
PTM
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).
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Anti-HGS antibodies
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CompareTarget: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6D11
Application*: WB, E
Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Cattle, Dog
Clone: CBFYH-1047
Application*: WB, IP, IF
Target: HGS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBFYH-1046
Application*: WB, P, F, IF
Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1045
Application*: E, IF, WB
Target: HGS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Human, Monkey
Clone: CBFYH-1044
Application*: WB, IP, P, IC
Target: HGS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1043
Application*: WB, IF
Target: HGS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYH-1039
Application*: IH, IP, WB
Target: HGS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYH-1038
Application*: WB, IH, IP, IF, IC
Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1040
Application*: E, IF, WB
Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1041
Application*: E, WB
Target: HGS
Sensitivity: 0.007 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Hgs
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1510
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 IHC: 1:50~1:100 ELISA: 1:40000
Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Cattle, Dog
Clone: D7T5N
Application*: WB, IP, IF (IC)
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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