HGS

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Biological Process
Endosomal transport Source: UniProtKB
Macroautophagy Source: ParkinsonsUK-UCL
Membrane invagination Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of receptor signaling pathway via JAK-STAT Source: HGNC-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of exosomal secretion Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein localization to membrane Source: UniProtKB
Protein targeting to lysosome Source: UniProtKB
Regulation of MAP kinase activity Source: UniProtKB
Regulation of protein catabolic process Source: HGNC-UCL
Signal transduction Source: ProtInc
Cellular Location
Early endosome membrane; Multivesicular body membrane; Cytoplasm. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
PTM
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).
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Anti-HGS antibodies

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Mouse Anti-HGS Recombinant Antibody (6D11) (CBMAB-A3879-LY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6D11
Application*: WB, E
Datasheet SDS

Rabbit Anti-HGS Recombinant Antibody (CBFYH-1047) (CBMAB-H1990-FY)

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Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Cattle, Dog
Clone: CBFYH-1047
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1046) (CBMAB-H1989-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBFYH-1046
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-HGS (AA 513-612) Recombinant Antibody (CBFYH-1045) (CBMAB-H1988-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1045
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1044) (CBMAB-H1987-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Human, Monkey
Clone: CBFYH-1044
Application*: WB, IP, P, IC
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1043) (CBMAB-H1986-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1043
Application*: WB, IF
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1039) (CBMAB-H1984-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYH-1039
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1038) (CBMAB-H1983-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYH-1038
Application*: WB, IH, IP, IF, IC
Datasheet SDS

Mouse Anti-HGS (AA 513-612) Recombinant Antibody (CBFYH-1040) (CBMAB-H0783-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1040
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HGS Recombinant Antibody (CBFYH-1041) (CBMAB-H0678-FY)

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Target: HGS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1041
Application*: E, WB
Datasheet SDS

Rabbit Anti-HGS Recombinant Antibody (EG1510) (CBMAB-EN1804-LY)

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Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1510
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 IHC: 1:50~1:100 ELISA: 1:40000
Datasheet SDS

Rabbit Anti-HGS Recombinant Antibody (D7T5N) (CBMAB-CP0952-LY)

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Target: HGS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Cattle, Dog
Clone: D7T5N
Application*: WB, IP, IF (IC)
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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