Human HGS ELISA Kit (V2LY-0626-LY4664)

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Tested Data
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Basic Information

Sensitivity
0.007 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
86.2 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Biological Process
Endosomal transport Source: UniProtKB
Macroautophagy Source: ParkinsonsUK-UCL
Membrane invagination Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of receptor signaling pathway via JAK-STAT Source: HGNC-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of exosomal secretion Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein localization to membrane Source: UniProtKB
Protein targeting to lysosome Source: UniProtKB
Regulation of MAP kinase activity Source: UniProtKB
Regulation of protein catabolic process Source: HGNC-UCL
Signal transduction Source: ProtInc
Cellular Location
Early endosome membrane; Multivesicular body membrane; Cytoplasm. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
PTM
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).

Yu, Z., Zeng, J., Wang, J., Cui, Y., Song, X., Zhang, Y., ... & Yang, X. (2021). Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovascular Research, 117(2), 533-546.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Hgs ELISA Kit (CAT#: V2LY-0626-LY2410)

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Isotype control

For research use only. Not intended for any clinical use.

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