HMGN1

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.

Full Name

high mobility group nucleosome binding domain 1

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Biological Process

Chromatin organization Source: GO_Central
Positive regulation of DNA-templated transcription, elongation Source: ProtInc

Cellular Location

Nucleus; Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

PTM

Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.

Anti-HMGN1 antibodies

Mouse Anti-HMGN1 Recombinant Antibody (IPO-38) (CBMAB-I0070-YY)

Datasheet

SDS

Target: HMGN1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: IPO-38

Application*: F, P, IF, E

Mouse Anti-HMGN1 Recombinant Antibody (CBFYH-1552) (CBMAB-H2528-FY)

Datasheet

SDS

Target: HMGN1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBFYH-1552

Application*: P

Rabbit Anti-HMGN1 Recombinant Antibody (D1I5O) (CBMAB-H2527-FY)

Datasheet

SDS

Target: HMGN1

Host: Rabbit

Specificity: Human, Monkey

Clone: D1I5O

Application*: WB, IP, IF

Rabbit Anti-HMGN1 Recombinant Antibody (EG1522) (CBMAB-EN1821-LY)

Datasheet

SDS

Target: HMGN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1522

Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)