HMGN1

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
Full Name
high mobility group nucleosome binding domain 1
Function
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Biological Process
Chromatin organization Source: GO_Central
Positive regulation of DNA-templated transcription, elongation Source: ProtInc
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
PTM
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
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Anti-HMGN1 antibodies

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Rabbit Anti-HMGN1 Recombinant Antibody (EG1522) (CBMAB-EN1821-LY)

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Target: HMGN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1522
Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000
Datasheet SDS

Mouse Anti-HMGN1 Recombinant Antibody (IPO-38) (CBMAB-I0070-YY)

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Target: HMGN1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: IPO-38
Application*: F, P, IF, E
Datasheet SDS

Mouse Anti-HMGN1 Recombinant Antibody (CBFYH-1552) (CBMAB-H2528-FY)

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Target: HMGN1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYH-1552
Application*: P
Datasheet SDS

Rabbit Anti-HMGN1 Recombinant Antibody (D1I5O) (CBMAB-H2527-FY)

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Target: HMGN1
Host: Rabbit
Specificity: Human, Monkey
Clone: D1I5O
Application*: WB, IP, IF
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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