HMOX2

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Full Name
Heme Oxygenase 2
Function
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Biological Process
Heme catabolic process Source: GO_Central
Heme oxidation Source: GO_Central
Iron ion homeostasis Source: GO_Central
Response to hypoxia Source: UniProtKB
Response to oxidative stress Source: GO_Central
Cellular Location
Microsome; Endoplasmic reticulum
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Anti-HMOX2 antibodies

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Mouse Anti-HMOX2 Recombinant Antibody (1D8-1A8) (CBMAB-A3978-LY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D8-1A8
Application*: WB, E
Datasheet SDS

Rabbit Anti-HMOX2 Recombinant Antibody (CBFYH-1584) (CBMAB-H2570-FY)

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Target: HMOX2
Host: Rabbit
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: CBFYH-1584
Application*: WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1583) (CBMAB-H2569-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1583
Application*: WB, IF
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1582) (CBMAB-H2568-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1582
Application*: F, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1581) (CBMAB-H2567-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1581
Application*: F, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1580) (CBMAB-H2566-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1580
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1579) (CBMAB-H2565-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1579
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1578) (CBMAB-H2564-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1578
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1577) (CBMAB-H2563-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1577
Application*: IH, WB
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1576) (CBMAB-H2562-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1576
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1575) (CBMAB-H2561-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1575
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-HMOX2 Recombinant Antibody (CBFYH-1574) (CBMAB-H2560-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1574
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-HMOX2 (AA 1-316) Recombinant Antibody (CBFYH-1572) (CBMAB-H2558-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1572
Application*: E, WB
Datasheet SDS

Mouse Anti-HMOX2 (AA 1-317) Monoclonal Antibody (CBFYH-3174) (CBMAB-H2557-FY)

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Target: HMOX2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3174
Application*: IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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