IL18RAP

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq]
Full Name
interleukin 18 receptor accessory protein
Function
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).

May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Interleukin-18-mediated signaling pathway Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 20-356
Helical: 357-377
Cytoplasmic: 378-599
PTM
N-glycosylated.
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Anti-IL18RAP antibodies

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Mouse Anti-IL18RAP Recombinant Antibody (4G4) (CBMAB-A4366-LY)

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Target: IL18RAP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G4
Application*: WB, E
Datasheet SDS

Mouse Anti-IL18RAP Recombinant Antibody (CBWJC-3809) (CBMAB-C5078WJ)

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Target: IL18RAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3809
Application*: FN
Datasheet SDS

Mouse Anti-IL18RAP Recombinant Antibody (B-B46) (CBMAB-I1971-YY)

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Target: IL18RAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-B46
Application*: F, E, FN
Datasheet SDS

Mouse Anti-IL18RAP Recombinant Antibody (CBYC-A985) (CBMAB-A4482-YC)

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Target: IL18RAP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-A985
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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