IL18RAP

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq]

Full Name

interleukin 18 receptor accessory protein

Function

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).

May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

Biological Process

Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Interleukin-18-mediated signaling pathway Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 20-356
Helical: 357-377
Cytoplasmic: 378-599

PTM

N-glycosylated.

Anti-IL18RAP antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-IL18RAP Recombinant Antibody (4G4) (CBMAB-A4366-LY)

Datasheet

SDS

Target: IL18RAP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4G4

Application*: WB, E

Mouse Anti-IL18RAP Recombinant Antibody (CBWJC-3809) (CBMAB-C5078WJ)

Datasheet

SDS

Target: IL18RAP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3809

Application*: FN

Mouse Anti-IL18RAP Recombinant Antibody (B-B46) (CBMAB-I1971-YY)

Datasheet

SDS

Target: IL18RAP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-B46

Application*: F, E, FN

Mouse Anti-IL18RAP Recombinant Antibody (CBYC-A985) (CBMAB-A4482-YC)

Datasheet

SDS

Target: IL18RAP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-A985

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)