Human Recombinant IL18RAP protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY4795)

Name: Human Recombinant IL18RAP protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY4795
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant IL18RAP protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-357 and predicts a molecular mass of 41.76 kDa.

Molecule Mass

41.76 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-357

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 18 receptor accessory protein

Function

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).

May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

Biological Process

Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Interleukin-18-mediated signaling pathway Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 20-356
Helical: 357-377
Cytoplasmic: 378-599

PTM

N-glycosylated.

Chen, W., Song, T., Zou, F., Xia, Y., Xing, J., Yu, W., ... & Cheng, F. (2023). Prognostic and immunological roles of IL18RAP in human cancers. Aging, 15.

Cherlin, S., Lewis, M. J., Plant, D., Nair, N., Goldmann, K., Tzanis, E., ... & MATURA Consortium. (2020). Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response. Annals of the rheumatic diseases, 79(11), 1446-1452.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Diptiranjan, S., Harshitha, S. M., Sibin, M. K., Arati, S., Chetan, G. K., & Bhat, D. I. (2019). Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population. Journal of Clinical Neuroscience, 66, 83-86.

Sibin, M. K., Harshitha, S. M., Arati, S., Chetan, G. K., Shukla, D. P., & Bhat, D. I. (2019). IL18RAP polymorphisms and its plasma levels in patients with Lumbar disc degeneration. Clinical Neurology and Neurosurgery, 184, 105374.

Ponasenko, A. V., Tsepokina, A. V., Khutornaya, M. V., Dolgikh, V. A., Malshev, I. Y., & Barbarash, O. L. (2018). The polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery disease. Translational Medicine, 5(4), 12-22.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL18RAP protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4793)

Human Recombinant IL18RAP protein, hFc Tag (CAT#: V2LY-0526-LY4794)

Human Recombinant IL18RAP protein, His Tag (CAT#: V2LY-0526-LY4796)

Mouse Recombinant IL18RAP protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8500)

Mouse Recombinant IL18RAP protein, His Tag (CAT#: V2LY-0526-LY8501)

Rat Recombinant IL18RAP protein, ECD, His Tag (CAT#: V2LY-0526-LY9446)

Rhesus Recombinant IL18RAP protein, hFc Tag (CAT#: V2LY-0526-LY9745)

Rhesus Recombinant IL18RAP protein, His Tag (CAT#: V2LY-0526-LY9746)

Rabbit Recombinant IL18RAP protein, ECD, His Tag (CAT#: V2LY-0526-LY9133)

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Human Recombinant IL18RAP protein, hFc Tag (CAT#: V2LY-0526-LY4794)

Rabbit Recombinant IL18RAP protein, ECD, His Tag (CAT#: V2LY-0526-LY9133)

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Rat Recombinant IL18RAP protein, ECD, His Tag (CAT#: V2LY-0526-LY9446)

Human Recombinant IL18RAP protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4793)

Mouse Recombinant IL18RAP protein, His Tag (CAT#: V2LY-0526-LY8501)

Human Recombinant IL18RAP protein, His Tag (CAT#: V2LY-0526-LY4796)

Rhesus Recombinant IL18RAP protein, hFc Tag (CAT#: V2LY-0526-LY9745)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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