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Mouse Anti-IL18RAP Recombinant Antibody (4G4) (CBMAB-A4366-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IL18RAP (NP_003844, 20 a.a. ~ 129 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 18 receptor accessory protein
Introduction
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq]
Entrez Gene ID
8807
UniProt ID
O95256
Alternative Names
ACPL; CD218b; CDw218b; IL18RB; MGC120589; MGC120590
Function
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).

May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Interleukin-18-mediated signaling pathway Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 20-356
Helical: 357-377
Cytoplasmic: 378-599
PTM
N-glycosylated.
More Infomation

Chen, W., Song, T., Zou, F., Xia, Y., Xing, J., Yu, W., ... & Cheng, F. (2023). Prognostic and immunological roles of IL18RAP in human cancers. Aging, 15.

Cherlin, S., Lewis, M. J., Plant, D., Nair, N., Goldmann, K., Tzanis, E., ... & MATURA Consortium. (2020). Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response. Annals of the rheumatic diseases, 79(11), 1446-1452.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Diptiranjan, S., Harshitha, S. M., Sibin, M. K., Arati, S., Chetan, G. K., & Bhat, D. I. (2019). Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population. Journal of Clinical Neuroscience, 66, 83-86.

Sibin, M. K., Harshitha, S. M., Arati, S., Chetan, G. K., Shukla, D. P., & Bhat, D. I. (2019). IL18RAP polymorphisms and its plasma levels in patients with Lumbar disc degeneration. Clinical Neurology and Neurosurgery, 184, 105374.

Ponasenko, A. V., Tsepokina, A. V., Khutornaya, M. V., Dolgikh, V. A., Malshev, I. Y., & Barbarash, O. L. (2018). The polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery disease. Translational Medicine, 5(4), 12-22.

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For research use only. Not intended for any clinical use.

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