Mouse Anti-IL18RAP Recombinant Antibody (CBWJC-3809) (CBMAB-C5078WJ)

Name: Mouse Anti-IL18RAP Recombinant Antibody (CBWJC-3809)
SKU: CBMAB-C5078WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-3809

Application

FuncS

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 18 receptor accessory protein

Introduction

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Entrez Gene ID

8807

UniProt ID

O95256

Alternative Names

Interleukin 18 Receptor Accessory Protein

Function

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).

May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

Biological Process

Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Interleukin-18-mediated signaling pathway Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 20-356
Helical: 357-377
Cytoplasmic: 378-599

PTM

N-glycosylated.

Chen, W., Song, T., Zou, F., Xia, Y., Xing, J., Yu, W., ... & Cheng, F. (2023). Prognostic and immunological roles of IL18RAP in human cancers. Aging, 15.

Cherlin, S., Lewis, M. J., Plant, D., Nair, N., Goldmann, K., Tzanis, E., ... & MATURA Consortium. (2020). Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response. Annals of the rheumatic diseases, 79(11), 1446-1452.

Ponasenko, A. V., Khutornaya, M. V., Malyshev, I. Y., & Barbarash, O. L. (2020). Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology, 25(10), 3977.

Diptiranjan, S., Harshitha, S. M., Sibin, M. K., Arati, S., Chetan, G. K., & Bhat, D. I. (2019). Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population. Journal of Clinical Neuroscience, 66, 83-86.

Sibin, M. K., Harshitha, S. M., Arati, S., Chetan, G. K., Shukla, D. P., & Bhat, D. I. (2019). IL18RAP polymorphisms and its plasma levels in patients with Lumbar disc degeneration. Clinical Neurology and Neurosurgery, 184, 105374.

Ponasenko, A. V., Tsepokina, A. V., Khutornaya, M. V., Dolgikh, V. A., Malshev, I. Y., & Barbarash, O. L. (2018). The polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery disease. Translational Medicine, 5(4), 12-22.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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