IL3RA
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Full Name
Interleukin 3 Receptor Subunit Alpha
Function
This is a receptor for interleukin-3.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 19-305
Helical: 306-325
Cytoplasmic: 326-378
Helical: 306-325
Cytoplasmic: 326-378
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Anti-IL3RA antibodies
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CompareTarget: IL3RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1367
Application*: F, IH, WB
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A567
Application*: FC, IHC, IP, WB
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB269
Application*: IF, FC
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB268
Application*: IF, FC
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB267
Application*: IF, FC
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 9G52
Application*: WB
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6A367
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: WA63
Application*: IF/IC, C
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJC-3830
Application*: WB
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2199
Application*: F
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1653
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-3025
Application*: F
Target: IL3RA
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0712
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2574
Application*: F, IC, IF, IH, N, WB
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0586
Application*: F
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2771
Application*: F
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1409
Application*: WB
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I1132
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8E11C5
Application*: WB, F, E, IH, IF, P, MC, IC
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBYY-I0713
Application*: WB, F, IH, C, IP
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6H2E3F3
Application*: E
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0516
Application*: C, P
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0215
Application*: WB, F
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0214
Application*: WB, F, MC
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 107D2.08
Application*: F, IH, IP, P, C
Target: IL3RA
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5B11
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7G3
Application*: F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6H6
Application*: F, C, P
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 32703
Application*: F, IC, IF, IH, N, WB
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2192
Application*: IH, IC, F
Target: IL3RA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3943
Application*: IC, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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