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Rat Anti-IL3RA Recombinant Antibody (CBYY-I0214) (CBMAB-I0566-YY)

This product is Rat antibody that recognizes IL3RA. The antibody CBYY-I0214 can be used for immunoassay techniques such as: WB, FC, CyTOF
See all IL3RA antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-I0214
Antibody Isotype
IgG2a
Application
WB, FC, CyTOF

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 3 Receptor Subunit Alpha
Introduction
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
Entrez Gene ID
16188
UniProt ID
P26952
Alternative Names
Interleukin 3 Receptor Subunit Alpha
Function
This is a receptor for interleukin-3.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 19-305
Helical: 306-325
Cytoplasmic: 326-378

Aisagbonhi, O., Bui, T., St. Louis, H., Pizzo, D., Meads, M., Mulholland, M., ... & Horii, M. (2023). RNA sequencing identifies human placental IL3RA as a potential predictor of adverse cardiovascular outcomes in patients with severe preeclampsia. medRxiv, 2023-06.

Qazi, S., & Uckun, F. M. (2022). Augmented expression of the IL3RA/CD123 gene in MLL/KMT2A-rearranged pediatric AML and infant ALL. Onco, 2(3), 245-263.

Yan, J., Hou, Z., Ren, Y., & Hu, J. (2022). EP300-ZNF384 Rearrangement Drive B-Cell Acute Lymphoblastic Leukemia Development By Activating IL3-IL3RA Signaling. Blood, 140(Supplement 1), 11508-11508.

Kirchhoff, D., Stelte-Ludwig, B., Lerchen, H. G., Wengner, A. M., Ahsen, O. V., Buchmann, P., ... & Sommer, A. (2020). IL3ra-targeting antibody–drug conjugate BAY-943 with a kinesin spindle protein inhibitor payload shows efficacy in preclinical models of hematologic malignancies. Cancers, 12(11), 3464.

Underwood, J. G., Smith, J. L., Call, L. F., Tseng, E., Hylkema, T. A., Ries, R. E., ... & Meshinchi, S. (2019). Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeutics. Blood, 134, 4658.

Sommer, A., Kirchhoff, D., Wengner, A. M., Stelte-Ludwig, B., Lerchen, H. G., Rebstock, A. S., ... & Kreft, B. (2019). Anti-tumor activity of BAY-943, an anti-IL3RA ADC with a novel KSP inhibitor payload, in CDX and PDX AML models. Cancer Research, 79(13_Supplement), 4828-4828.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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