Human Recombinant IL3RA protein, ECD, His Tag-1 (V2LY-0526-LY4915)

Name: Human Recombinant IL3RA protein, ECD, His Tag-1
SKU: V2LY-0526-LY4915
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL3RA protein, ECD, His Tag consist of Amino Acid: 1-304 and predicts a molecular mass of 34.5 kDa.

Molecule Mass

34.5 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 1-304

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 3 Receptor Subunit Alpha

Function

This is a receptor for interleukin-3.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 19-305
Helical: 306-325
Cytoplasmic: 326-378

Aisagbonhi, O., Bui, T., St. Louis, H., Pizzo, D., Meads, M., Mulholland, M., ... & Horii, M. (2023). RNA sequencing identifies human placental IL3RA as a potential predictor of adverse cardiovascular outcomes in patients with severe preeclampsia. medRxiv, 2023-06.

Qazi, S., & Uckun, F. M. (2022). Augmented expression of the IL3RA/CD123 gene in MLL/KMT2A-rearranged pediatric AML and infant ALL. Onco, 2(3), 245-263.

Yan, J., Hou, Z., Ren, Y., & Hu, J. (2022). EP300-ZNF384 Rearrangement Drive B-Cell Acute Lymphoblastic Leukemia Development By Activating IL3-IL3RA Signaling. Blood, 140(Supplement 1), 11508-11508.

Kirchhoff, D., Stelte-Ludwig, B., Lerchen, H. G., Wengner, A. M., Ahsen, O. V., Buchmann, P., ... & Sommer, A. (2020). IL3ra-targeting antibody–drug conjugate BAY-943 with a kinesin spindle protein inhibitor payload shows efficacy in preclinical models of hematologic malignancies. Cancers, 12(11), 3464.

Underwood, J. G., Smith, J. L., Call, L. F., Tseng, E., Hylkema, T. A., Ries, R. E., ... & Meshinchi, S. (2019). Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeutics. Blood, 134, 4658.

Sommer, A., Kirchhoff, D., Wengner, A. M., Stelte-Ludwig, B., Lerchen, H. G., Rebstock, A. S., ... & Kreft, B. (2019). Anti-tumor activity of BAY-943, an anti-IL3RA ADC with a novel KSP inhibitor payload, in CDX and PDX AML models. Cancer Research, 79(13_Supplement), 4828-4828.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant CD123 protein, His Tag (CAT#: V2LY-0526-LY1286)

Cynomolgus Recombinant CD123 protein, His Tag (CAT#: V2LY-0526-LY1573)

Human Recombinant IL3RA protein, ECD, His Tag (CAT#: V2LY-0526-LY4914)

Human Recombinant IL3RA protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4916)

Human Recombinant IL3RA protein, hFc Tag (CAT#: V2LY-0526-LY4917)

Human Recombinant IL3RA protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4918)

Mouse Recombinant IL3RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8543)

Mouse Recombinant IL3RA protein, ECD, His Tag (CAT#: V2LY-0526-LY8544)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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