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Mouse Anti-IL3RA Recombinant Antibody (CBYY-C2574) (CBMAB-C4015-YY)

This product is mouse antibody that recognizes IL3RA. The antibody CBYY-C2574 can be used for immunoassay techniques such as: FC, ICC, IF, IHC, Neut, WB
See all IL3RA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2574
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC, Neut, WB

Basic Information

Immunogen
Sf 21-derived recombinant human IL-3R alpha/CD123 Lys20-Arg305, predicted
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.5 mg/mL
Preservative
PBS, 5% trehalose
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 3 Receptor Subunit Alpha
Entrez Gene ID
3563
UniProt ID
P26951
Alternative Names
Keratin 19; 40-KDa Keratin Intermediate Filament; Keratin, Type I Cytoskeletal 19; Keratin, Type I, 40-Kd; Keratin 19, Type I; Cytokeratin 19; CK-19;
Function
This is a receptor for interleukin-3.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 19-305
Helical: 306-325
Cytoplasmic: 326-378

Aisagbonhi, O., Bui, T., St. Louis, H., Pizzo, D., Meads, M., Mulholland, M., ... & Horii, M. (2023). RNA sequencing identifies human placental IL3RA as a potential predictor of adverse cardiovascular outcomes in patients with severe preeclampsia. medRxiv, 2023-06.

Qazi, S., & Uckun, F. M. (2022). Augmented expression of the IL3RA/CD123 gene in MLL/KMT2A-rearranged pediatric AML and infant ALL. Onco, 2(3), 245-263.

Yan, J., Hou, Z., Ren, Y., & Hu, J. (2022). EP300-ZNF384 Rearrangement Drive B-Cell Acute Lymphoblastic Leukemia Development By Activating IL3-IL3RA Signaling. Blood, 140(Supplement 1), 11508-11508.

Kirchhoff, D., Stelte-Ludwig, B., Lerchen, H. G., Wengner, A. M., Ahsen, O. V., Buchmann, P., ... & Sommer, A. (2020). IL3ra-targeting antibody–drug conjugate BAY-943 with a kinesin spindle protein inhibitor payload shows efficacy in preclinical models of hematologic malignancies. Cancers, 12(11), 3464.

Underwood, J. G., Smith, J. L., Call, L. F., Tseng, E., Hylkema, T. A., Ries, R. E., ... & Meshinchi, S. (2019). Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeutics. Blood, 134, 4658.

Sommer, A., Kirchhoff, D., Wengner, A. M., Stelte-Ludwig, B., Lerchen, H. G., Rebstock, A. S., ... & Kreft, B. (2019). Anti-tumor activity of BAY-943, an anti-IL3RA ADC with a novel KSP inhibitor payload, in CDX and PDX AML models. Cancer Research, 79(13_Supplement), 4828-4828.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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