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ITGB1BP2

This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains.

Full Name

integrin beta 1 binding protein (melusin) 2

Function

May play a role during maturation and/or organization of muscles cells.

Biological Process

Muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Z disc

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Anti-ITGB1BP2 antibodies

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Mouse Anti-ITGB1BP2 Recombinant Antibody (3G9) (CBMAB-A4585-LY)

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Target: ITGB1BP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G9

Application*: WB, E

Mouse Anti-ITGB1BP2 (AA 61-258) Recombinant Antibody (CBFYM-1161) (CBMAB-M1318-FY)

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Target: ITGB1BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Human, Mouse

Clone: CBFYM-1161

Application*: WB, IF

Mouse Anti-ITGB1BP2 (AA 2-347) Recombinant Antibody (CBFYM-1160) (CBMAB-M1317-FY)

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Target: ITGB1BP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1160

Application*: WB, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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