JTB

JTB is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

jumping translocation breakpoint

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity).
Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Apoptotic processIEA:UniProtKB-KW
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB

Membrane; Mitochondrion; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Extracellular: 31-105
Helical: 106-126
Cytoplasmic: 127-146