Rabbit Anti-JTB Recombinant Antibody (EG1723) (CBMAB-EN2061-LY)

Name: Rabbit Anti-JTB Recombinant Antibody (EG1723)
SKU: CBMAB-EN2061-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1723

Application

WB: 1:500~1:1000 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from N-terminal of human JTB.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

jumping translocation breakpoint

Entrez Gene ID

5602

UniProt ID

O76095

Alternative Names

PAR; hJT; HJTB; HSPC222

Function

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity).
Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane; Mitochondrion; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Topology

Extracellular: 31-105
Helical: 106-126
Cytoplasmic: 127-146

Jayathirtha, M., Jayaweera, T., Whitham, D., Petre, B. A., Neagu, A. N., & Darie, C. C. (2023). Two-Dimensional Polyacrylamide Gel Electrophoresis Coupled with Nanoliquid Chromatography–Tandem Mass Spectrometry-Based Identification of Differentially Expressed Proteins and Tumorigenic Pathways in the MCF7 Breast Cancer Cell Line Transfected for Jumping Translocation Breakpoint Protein Overexpression. International Journal of Molecular Sciences, 24(19), 14714.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(4), 1784.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of downregulation of jumping translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(9), 4373.

Jayathirtha, M., Whitham, D., Alwine, S., Donnelly, M., Neagu, A. N., & Darie, C. C. (2022). Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells. Molecules, 27(23), 8301.

Jayathirtha, M., Whitham, D., Channaveerappa, D., & Darie, C. (2022). Mass Spectrometry based Proteomics to Investigate and Characterize the Human Jumping Translocation Breakpoint (hJTB) Protein using Cancer Cell Lines. The FASEB Journal, 36.

Jayathirtha, M., Channaveerappa, D., & Darie, C. (2021). Investigation and Characterization of the Jumping Translocation Breakpoint (JTB) Protein using Mass Spectrometry based Proteomics. The FASEB Journal, 35.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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