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Mouse Anti-JTB Recombinant Antibody (4E7) (CBMAB-0215-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E7
Antibody Isotype
IgG2a, Κ
Application
ELISA, WB

Basic Information

Immunogen
JTB (amino acid 1-147) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
jumping translocation breakpoint
Introduction
JTB is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
Entrez Gene ID
10899
UniProt ID
O76095
Alternative Names
PAR; hJT; HJTB; HSPC222
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity).
Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane; Mitochondrion; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Topology
Extracellular: 31-105
Helical: 106-126
Cytoplasmic: 127-146
More Infomation

Jayathirtha, M., Jayaweera, T., Whitham, D., Petre, B. A., Neagu, A. N., & Darie, C. C. (2023). Two-Dimensional Polyacrylamide Gel Electrophoresis Coupled with Nanoliquid Chromatography–Tandem Mass Spectrometry-Based Identification of Differentially Expressed Proteins and Tumorigenic Pathways in the MCF7 Breast Cancer Cell Line Transfected for Jumping Translocation Breakpoint Protein Overexpression. International Journal of Molecular Sciences, 24(19), 14714.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(4), 1784.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of downregulation of jumping translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(9), 4373.

Jayathirtha, M., Whitham, D., Alwine, S., Donnelly, M., Neagu, A. N., & Darie, C. C. (2022). Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells. Molecules, 27(23), 8301.

Jayathirtha, M., Whitham, D., Channaveerappa, D., & Darie, C. (2022). Mass Spectrometry based Proteomics to Investigate and Characterize the Human Jumping Translocation Breakpoint (hJTB) Protein using Cancer Cell Lines. The FASEB Journal, 36.

Jayathirtha, M., Channaveerappa, D., & Darie, C. (2021). Investigation and Characterization of the Jumping Translocation Breakpoint (JTB) Protein using Mass Spectrometry based Proteomics. The FASEB Journal, 35.

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For research use only. Not intended for any clinical use.

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