Human JTB ELISA Kit (V2LY-0626-LY5102)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0044 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
16.4 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
jumping translocation breakpoint
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity).
Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane; Mitochondrion; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Topology
Extracellular: 31-105
Helical: 106-126
Cytoplasmic: 127-146

Jayathirtha, M., Jayaweera, T., Whitham, D., Petre, B. A., Neagu, A. N., & Darie, C. C. (2023). Two-Dimensional Polyacrylamide Gel Electrophoresis Coupled with Nanoliquid Chromatography–Tandem Mass Spectrometry-Based Identification of Differentially Expressed Proteins and Tumorigenic Pathways in the MCF7 Breast Cancer Cell Line Transfected for Jumping Translocation Breakpoint Protein Overexpression. International Journal of Molecular Sciences, 24(19), 14714.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(4), 1784.

Jayathirtha, M., Neagu, A. N., Whitham, D., Alwine, S., & Darie, C. C. (2022). Investigation of the effects of downregulation of jumping translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in breast cancer. American Journal of Cancer Research, 12(9), 4373.

Jayathirtha, M., Whitham, D., Alwine, S., Donnelly, M., Neagu, A. N., & Darie, C. C. (2022). Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells. Molecules, 27(23), 8301.

Jayathirtha, M., Whitham, D., Channaveerappa, D., & Darie, C. (2022). Mass Spectrometry based Proteomics to Investigate and Characterize the Human Jumping Translocation Breakpoint (hJTB) Protein using Cancer Cell Lines. The FASEB Journal, 36.

Jayathirtha, M., Channaveerappa, D., & Darie, C. (2021). Investigation and Characterization of the Jumping Translocation Breakpoint (JTB) Protein using Mass Spectrometry based Proteomics. The FASEB Journal, 35.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant JTB protein, Fc Tag (CAT#: V2LY-0526-LY5115)

Related Products

Human Recombinant JTB protein, Fc Tag (CAT#: V2LY-0526-LY5115)

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Mouse Anti-JTB Recombinant Antibody (4E7) (CAT#: CBMAB-0215-WJ)

Mouse Anti-JTB Recombinant Antibody (CBFYJ-014) (CAT#: CBMAB-0026-FY)

Mouse Anti-JTB Recombinant Antibody (CBFYJ-011) (CAT#: CBMAB-0023-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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