KCNG3

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms.

Full Name

potassium voltage-gated channel modifier subfamily G member 3

Function

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086).
Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Cell membrane; Cytoplasm. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745).
Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135).
Remains intracellular in the absence of KCNB1 (PubMed:12060745).

Topology

Cytoplasmic: 1-168
Helical: 169-190
Extracellular: 191-220
Helical: 221-242
Cytoplasmic: 243-253
Helical: 254-274
Extracellular: 275-284
Helical: 285-305
Cytoplasmic: 306-320
Helical: 321-342
Extracellular: 343-360
Helical: 361-380
Extracellular: 381-387
Helical: 388-416
Cytoplasmic: 417-436