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Mouse Anti-KCNG3 Recombinant Antibody (5H2) (CBMAB-K0533-LY)

This product is antibody recognizes KCNG3. The antibody 5H2 immunoassay techniques such as: ELISA.
See all KCNG3 antibodies
Published Data
Fig.1 Association of hKv6.3 with hKv2.1 in co-transfected COS7 cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5H2
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
KCNG3 (23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel modifier subfamily G member 3
Introduction
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
170850
UniProt ID
Q8TAE7
Alternative Names
Potassium Voltage-Gated Channel Modifier Subfamily G Member 3; Potassium Voltage-Gated Channel; Subfamily G; Member 3; Voltage-Gated Potassium Channel Subunit Kv10.1; Voltage-Gated Potassium Channel Subunit Kv6.3; Potassium Channel; Voltage Gated Modifier Subfamily G; Member 3; Potassium Voltage-Gated Channel Subfamily G Member 3;
Function
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086).
Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).
Biological Process
Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Cellular Location
Cell membrane; Cytoplasm. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745).
Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135).
Remains intracellular in the absence of KCNB1 (PubMed:12060745).
Topology
Cytoplasmic: 1-168
Helical: 169-190
Extracellular: 191-220
Helical: 221-242
Cytoplasmic: 243-253
Helical: 254-274
Extracellular: 275-284
Helical: 285-305
Cytoplasmic: 306-320
Helical: 321-342
Extracellular: 343-360
Helical: 361-380
Extracellular: 381-387
Helical: 388-416
Cytoplasmic: 417-436
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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