Mouse Anti-KCNG3 Recombinant Antibody (5H2) (CBMAB-K0533-LY)

Name: Mouse Anti-KCNG3 Recombinant Antibody (5H2)
SKU: CBMAB-K0533-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5H2

Application

ELISA

Immunogen

KCNG3 (23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium voltage-gated channel modifier subfamily G member 3

Introduction

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Entrez Gene ID

170850

UniProt ID

Q8TAE7

Alternative Names

Potassium Voltage-Gated Channel Modifier Subfamily G Member 3; Potassium Voltage-Gated Channel; Subfamily G; Member 3; Voltage-Gated Potassium Channel Subunit Kv10.1; Voltage-Gated Potassium Channel Subunit Kv6.3; Potassium Channel; Voltage Gated Modifier Subfamily G; Member 3; Potassium Voltage-Gated Channel Subfamily G Member 3;

Function

Potassium channel subunit that does not form functional channels by itself (PubMed:11852086).
Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Cell membrane; Cytoplasm. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745).
Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135).
Remains intracellular in the absence of KCNB1 (PubMed:12060745).

Topology

Cytoplasmic: 1-168
Helical: 169-190
Extracellular: 191-220
Helical: 221-242
Cytoplasmic: 243-253
Helical: 254-274
Extracellular: 275-284
Helical: 285-305
Cytoplasmic: 306-320
Helical: 321-342
Extracellular: 343-360
Helical: 361-380
Extracellular: 381-387
Helical: 388-416
Cytoplasmic: 417-436

O’Donnell, A. M., Nakamura, H., Tomuschat, C., Marayati, N. F., & Puri, P. (2019). Altered expression of KCNG3 and KCNG4 in Hirschsprung’s disease. Pediatric surgery international, 35, 193-197.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-KCNG3 Recombinant Antibody (EG1754) (CAT#: CBMAB-EN2093-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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