KHK
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Full Name
Ketohexokinase
Function
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Biological Process
Fructose metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of glycogen metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to fructoseManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseManual Assertion Based On ExperimentIBA:GO_Central
Response to insulinManual Assertion Based On ExperimentIBA:GO_Central
Response to sucroseManual Assertion Based On ExperimentIBA:GO_Central
Response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of glycogen metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to fructoseManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseManual Assertion Based On ExperimentIBA:GO_Central
Response to insulinManual Assertion Based On ExperimentIBA:GO_Central
Response to sucroseManual Assertion Based On ExperimentIBA:GO_Central
Response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm; Cytosol; Extracellular exosome
Involvement in disease
Fructosuria (FRUCT):
Benign defect of intermediary metabolism.
Benign defect of intermediary metabolism.
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Anti-KHK antibodies
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CompareTarget: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F1
Application*: F, IF, WB
Target: KHK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-075
Application*: WB, IP, P, IC/IF
Target: KHK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: S1
Application*: E, IF, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H3
Application*: F, IC/IF, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E9
Application*: F, IC/IF, IH, P, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D1
Application*: F, IF, IH, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C4
Application*: F, IH
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C3
Application*: F, IF, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B1
Application*: E, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H6-2B6
Application*: E, WB
Target: KHK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D8
Application*: F, IF, P, WB
Target: KHK
Sensitivity: 5.27 mU/mL
Detection Range: 10-2000 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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