KHK Matched Antibody Pair (659) (APMAB-659LY)

Name: KHK Matched Antibody Pair (659)
SKU: APMAB-659LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-KHK polyclonal antibody, 100 ug

Detection Antibody

Anti-KHK Mouse monoclonal, IgG2a antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Alternative Names

Ketohexokinase; Hepatic Fructokinase; Fructokinase; Testicular Tissue Protein Li 102; Ketohexokinase (Fructokinase); EC 2.7.1.3;

Entrez Gene ID

3795

UniProt ID

P50053

More Infomation

Helsley, R. N., Park, S. H., Vekaria, H. J., Sullivan, P. G., Conroy, L. R., Sun, R. C., ... & Softic, S. (2023). Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation. Journal of Hepatology, 79(1), 25-42.

Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., ... & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science Advances, 8(14), eabm7985.

Shepherd, E. L., Saborano, R., Northall, E., Matsuda, K., Ogino, H., Yashiro, H., ... & Lalor, P. F. (2021). Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. JHEP Reports, 3(2), 100217.

Kim, J., Kang, J., Kang, Y. L., Woo, J., Kim, Y., Huh, J., & Park, J. W. (2020). Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. Nature communications, 11(1), 5436.

Futatsugi, K., Smith, A. C., Tu, M., Raymer, B., Ahn, K., Coffey, S. B., ... & Magee, T. V. (2020). Discovery of PF-06835919: a potent inhibitor of ketohexokinase (KHK) for the treatment of metabolic disorders driven by the overconsumption of fructose. Journal of Medicinal Chemistry, 63(22), 13546-13560.

Hayasaki, T., Ishimoto, T., Doke, T., Hirayama, A., Soga, T., Furuhashi, K., ... & Kadomatsu, K. (2019). Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase. The Journal of Nutritional Biochemistry, 71, 54-62.

Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., ... & Tolan, D. R. (2018). Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. The Journal of clinical investigation, 128(6), 2226-2238.

Gao, W., Li, N., Li, Z., Xu, J., & Su, C. (2018). Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. Biochemical and biophysical research communications, 503(3), 1298-1306.

Miller, C. O., Yang, X., Lu, K., Cao, J., Herath, K., Rosahl, T. W., ... & Akiyama, T. E. (2018). Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects. American Journal of Physiology-Endocrinology and Metabolism, 315(3), E386-E393.

Liu, D., Sterpka, J. A., Vatner, D. F., Bell, M., Murray, S., Bhanot, S., ... & Samuel, V. (2018). Targeting ketohexokinase (KHK) with a novel antisense oligonucleotide (ASO) decreases de novo lipogenesis and improves insulin-mediated whole body glucose metabolism. Diabetes, 67(Supplement_1).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human KHK ELISA Kit (CAT#: V2LY-0626-LY5925)

KHK Matched Antibody Pair (658) (CAT#: APMAB-658LY)

KHK Matched Antibody Pair (660) (CAT#: APMAB-660LY)

Antibody Pairs

KHK Matched Antibody Pair (658) (CAT#: APMAB-658LY)

KHK Matched Antibody Pair (660) (CAT#: APMAB-660LY)

Related Products

Mouse Anti-KHK Recombinant Antibody (4H3) (CAT#: CBMAB-K0814-LY)

Mouse Anti-KHK Recombinant Antibody (3C4) (CAT#: CBMAB-K0810-LY)

Mouse Anti-KHK Recombinant Antibody (1F1) (CAT#: CBMAB-K0806-LY)

Human KHK ELISA Kit (CAT#: V2LY-0626-LY5925)

Mouse Anti-KHK Recombinant Antibody (1H6-2B6) (CAT#: CBMAB-K0807-LY)

Mouse Anti-KHK Recombinant Antibody (S1) (CAT#: CBMAB-K0815-LY)

KHK Matched Antibody Pair (658) (CAT#: APMAB-658LY)

Mouse Anti-KHK Recombinant Antibody (2B1) (CAT#: CBMAB-K0808-LY)

Mouse Anti-KHK Recombinant Antibody (4E9) (CAT#: CBMAB-K0813-LY)

Mouse Anti-KHK Recombinant Antibody (3D1) (CAT#: CBMAB-K0811-LY)

Isotype control

For research use only. Not intended for any clinical use.

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