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KHK Matched Antibody Pair (659) (APMAB-659LY)

This antibody pair set can be used for detecting and quantifying protein level of human KHK.
See all KHK antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-KHK polyclonal antibody, 100 ug
Detection Antibody
Anti-KHK Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
Ketohexokinase; Hepatic Fructokinase; Fructokinase; Testicular Tissue Protein Li 102; Ketohexokinase (Fructokinase); EC 2.7.1.3;
Entrez Gene ID
3795
UniProt ID
P50053

Helsley, R. N., Park, S. H., Vekaria, H. J., Sullivan, P. G., Conroy, L. R., Sun, R. C., ... & Softic, S. (2023). Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation. Journal of Hepatology, 79(1), 25-42.

Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., ... & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science Advances, 8(14), eabm7985.

Shepherd, E. L., Saborano, R., Northall, E., Matsuda, K., Ogino, H., Yashiro, H., ... & Lalor, P. F. (2021). Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. JHEP Reports, 3(2), 100217.

Kim, J., Kang, J., Kang, Y. L., Woo, J., Kim, Y., Huh, J., & Park, J. W. (2020). Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. Nature communications, 11(1), 5436.

Futatsugi, K., Smith, A. C., Tu, M., Raymer, B., Ahn, K., Coffey, S. B., ... & Magee, T. V. (2020). Discovery of PF-06835919: a potent inhibitor of ketohexokinase (KHK) for the treatment of metabolic disorders driven by the overconsumption of fructose. Journal of Medicinal Chemistry, 63(22), 13546-13560.

Hayasaki, T., Ishimoto, T., Doke, T., Hirayama, A., Soga, T., Furuhashi, K., ... & Kadomatsu, K. (2019). Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase. The Journal of Nutritional Biochemistry, 71, 54-62.

Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., ... & Tolan, D. R. (2018). Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. The Journal of clinical investigation, 128(6), 2226-2238.

Gao, W., Li, N., Li, Z., Xu, J., & Su, C. (2018). Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. Biochemical and biophysical research communications, 503(3), 1298-1306.

Miller, C. O., Yang, X., Lu, K., Cao, J., Herath, K., Rosahl, T. W., ... & Akiyama, T. E. (2018). Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects. American Journal of Physiology-Endocrinology and Metabolism, 315(3), E386-E393.

Liu, D., Sterpka, J. A., Vatner, D. F., Bell, M., Murray, S., Bhanot, S., ... & Samuel, V. (2018). Targeting ketohexokinase (KHK) with a novel antisense oligonucleotide (ASO) decreases de novo lipogenesis and improves insulin-mediated whole body glucose metabolism. Diabetes, 67(Supplement_1).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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