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KRT4

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Full Name

Keratin 4

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB

Cellular Location

Cell surface
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus

Involvement in disease

White sponge nevus 1 (WSN1):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Anti-KRT4 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-KRT4 Recombinant Antibody (A830) (CBMAB-AP4099LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: A830

Application*: ICC, IHC, IP, WB

Rabbit Anti-KRT4 Recombinant Antibody (RM355) (CBMAB-BR330LY)

SDS

Target: KRT4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: RM355

Application*: IHC, WB

Mouse Anti-KRT4 Recombinant Antibody (CBCNC-641) (CBMAB-C3853-CN)

SDS

Target: KRT4

Host: Mouse

Specificity: Human

Clone: CBCNC-641

Application*: WB, ICC, P, IH-F, E

Mouse Anti-KRT4 Recombinant Antibody (CBWJC-4053) (CBMAB-C5382WJ)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBWJC-4053

Application*: E, IH, WB

Mouse Anti-KRT4 Recombinant Antibody (CBWJC-4052) (CBMAB-C5381WJ)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Cattle, Human

Clone: CBWJC-4052

Application*: P, C, IC

Rabbit Anti-KRT4 Recombinant Antibody (CBWJC-2293) (CBMAB-C3176WJ)

SDS

Target: KRT4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-2293

Application*: WB, IP, P, IC, F, IC

Mouse Anti-KRT4 Recombinant Antibody (C11) (CBMAB-C3175WJ)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: C11

Application*: F

Mouse Anti-KRT4 Recombinant Antibody (CBXC-1404) (CBMAB-C4574-CQ)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBXC-1404

Application*: IF, IH, IP, WB

Mouse Anti-KRT4 Recombinant Antibody (CBYY-C2611) (CBMAB-C4052-YY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Cat, Human

Clone: CBYY-C2611

Application*: F, IH, WB

Mouse Anti-KRT4 Recombinant Antibody (CBFYC-2893) (CBMAB-C2969-FY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBFYC-2893

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-KRT4 Recombinant Antibody (CBFYM-1197) (CBMAB-M1354-FY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Guinea pig, Human, Mouse, Rat, Cattle, Goat, Frog, Pig

Clone: CBFYM-1197

Application*: WB, P, IF, F

Mouse Anti-KRT4 Recombinant Antibody (4A37) (CBMAB-C6590-LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Ferret, Human

Clone: 4A37

Application*: F, C, WB

Mouse Anti-KRT4 Recombinant Antibody (1) (CBMAB-C1940-LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: 1

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-KRT4 Recombinant Antibody (CK-4) (CBMAB-K1882-LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CK-4

Application*: IH, IP

Mouse Anti-KRT4 Recombinant Antibody (6B10) (CBMAB-K1881-LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6B10

Application*: F, IC, C, WB

Mouse Anti-KRT4 Recombinant Antibody (15j137) (CBMAB-K1879-LY)

SDS

Target: KRT4

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: 15j137

Application*: E, IC, IH, WB

Rabbit Anti-KRT4 Recombinant Antibody (CBLY1-153) (CBMAB-K1878-LY)

SDS

Target: KRT4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: CBLY1-153

Application*: IC, IH, WB

KRT4 Matched Antibody Pair (675) (APMAB-675LY)

SDS

Target: KRT4

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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