KRT4
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Full Name
Keratin 4
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Cellular Location
Cell surface
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 1 (WSN1):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
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Anti-KRT4 antibodies
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Target: KRT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A830
Application*: ICC, IHC, IP, WB
Target: KRT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM355
Application*: IHC, WB
Target: KRT4
Host: Mouse
Specificity: Human
Clone: CBCNC-641
Application*: WB, ICC, P, IH-F, E
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBWJC-4053
Application*: E, IH, WB
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human
Clone: CBWJC-4052
Application*: P, C, IC
Target: KRT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2293
Application*: WB, IP, P, IC, F, IC
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C11
Application*: F
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXC-1404
Application*: IF, IH, IP, WB
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Cat, Human
Clone: CBYY-C2611
Application*: F, IH, WB
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYC-2893
Application*: WB, IC, P, C, E, IP, IF, F
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig, Human, Mouse, Rat, Cattle, Goat, Frog, Pig
Clone: CBFYM-1197
Application*: WB, P, IF, F
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Ferret, Human
Clone: 4A37
Application*: F, C, WB
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: 1
Application*: WB, IC, P, C, E, IP, IF, F
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CK-4
Application*: IH, IP
Target: KRT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B10
Application*: F, IC, C, WB
Target: KRT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 15j137
Application*: E, IC, IH, WB
Target: KRT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBLY1-153
Application*: IC, IH, WB
Target: KRT4
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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