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KRT4 Matched Antibody Pair (675) (APMAB-675LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-KRT4 polyclonal antibody, 100 ug
Detection Antibody
Anti-KRT4 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Alternative Names
Keratin 4; CYK4; Keratin, Type II Cytoskeletal 4; Type-II Keratin Kb4; Cytokeratin 4; CK-4; K4;
Entrez Gene ID
3851
UniProt ID
P19013
More Infomation

Li, X., Fang, J., Tao, X., Xia, J., Cheng, B., & Wang, Y. (2023). Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. PeerJ, 11, e14824.

Takan, I., Karakülah, G., Louka, A., & Pavlopoulou, A. (2023). “In the light of evolution:” keratins as exceptional tumor biomarkers. PeerJ, 11, e15099.

Hu, W. Y., Hu, D. P., Xie, L., Nonn, L., Lu, R., Abern, M., ... & Prins, G. S. (2021). Keratin profiling by single-cell RNA-sequencing identifies human prostate stem cell lineage hierarchy and cancer stem-like cells. International Journal of Molecular Sciences, 22(15), 8109.

Kanazawa, H., Kita, A., Ishida, N., Miyamoto, I., Kasamatsu, A., & Uzawa, K. (2020). Sporadic white sponge nevus caused by a mutation in the keratin 4 gene. Oral and Maxillofacial Surgery Cases, 6(4), 100190.

Takashima, K., Fujii, S., Komatsuzaki, R., Komatsu, M., Takahashi, M., Kojima, T., ... & Yano, T. (2020). CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. International Journal of Oncology, 56(3), 835-847.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Zhang, J., Quan, J., Ren, Y., Chen, M., Yang, J., & Zhang, X. (2018). Keratin 4 regulates the development of human white sponge nevus. Journal of Oral Pathology & Medicine, 47(6), 598-605.

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For research use only. Not intended for any clinical use.

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