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Mouse Anti-KRT4 Recombinant Antibody (CBYY-C2611) (CBMAB-C4052-YY)

This product is mouse antibody that recognizes KRT4. The antibody CBYY-C2611 can be used for immunoassay techniques such as: FC, IHC, WB
See all KRT4 antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Cat, Human
Clone
CBYY-C2611
Antibody Isotype
IgG1
Application
FC, IHC, WB

Basic Information

Immunogen
Cytokeratin 4
Specificity
Dog, Cat, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
1 mg/mL
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 4
Entrez Gene ID
Human3851
Dog100682832
Cat101080551
UniProt ID
HumanP19013
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Cellular Location
Cell surface
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 1 (WSN1):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Li, X., Fang, J., Tao, X., Xia, J., Cheng, B., & Wang, Y. (2023). Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. PeerJ, 11, e14824.

Takan, I., Karakülah, G., Louka, A., & Pavlopoulou, A. (2023). “In the light of evolution:” keratins as exceptional tumor biomarkers. PeerJ, 11, e15099.

Hu, W. Y., Hu, D. P., Xie, L., Nonn, L., Lu, R., Abern, M., ... & Prins, G. S. (2021). Keratin profiling by single-cell RNA-sequencing identifies human prostate stem cell lineage hierarchy and cancer stem-like cells. International Journal of Molecular Sciences, 22(15), 8109.

Kanazawa, H., Kita, A., Ishida, N., Miyamoto, I., Kasamatsu, A., & Uzawa, K. (2020). Sporadic white sponge nevus caused by a mutation in the keratin 4 gene. Oral and Maxillofacial Surgery Cases, 6(4), 100190.

Takashima, K., Fujii, S., Komatsuzaki, R., Komatsu, M., Takahashi, M., Kojima, T., ... & Yano, T. (2020). CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. International Journal of Oncology, 56(3), 835-847.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Zhang, J., Quan, J., Ren, Y., Chen, M., Yang, J., & Zhang, X. (2018). Keratin 4 regulates the development of human white sponge nevus. Journal of Oral Pathology & Medicine, 47(6), 598-605.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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