Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KRT4 Recombinant Antibody (CBLY1-153) (CBMAB-K1878-LY)

This product is antibody recognizes KRT4. The antibody CBLY1-153 immunoassay techniques such as: ICC, IHC, WB.
See all KRT4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
CBLY1-153
Antibody Isotype
IgG
Application
ICC, IHC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues in human Cytokeratin 4 was used as an immunogen
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 4
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3851
Rat315323
UniProt ID
HumanP19013
RatQ6IG00
Alternative Names
Keratin 4; CYK4; Keratin; Type II Cytoskeletal 4; Type-II Keratin Kb4; Cytokeratin 4; CK-4; K4;
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Cellular Location
Cell surface
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 1 (WSN1):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Li, X., Fang, J., Tao, X., Xia, J., Cheng, B., & Wang, Y. (2023). Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. PeerJ, 11, e14824.

Takan, I., Karakülah, G., Louka, A., & Pavlopoulou, A. (2023). “In the light of evolution:” keratins as exceptional tumor biomarkers. PeerJ, 11, e15099.

Hu, W. Y., Hu, D. P., Xie, L., Nonn, L., Lu, R., Abern, M., ... & Prins, G. S. (2021). Keratin profiling by single-cell RNA-sequencing identifies human prostate stem cell lineage hierarchy and cancer stem-like cells. International Journal of Molecular Sciences, 22(15), 8109.

Kanazawa, H., Kita, A., Ishida, N., Miyamoto, I., Kasamatsu, A., & Uzawa, K. (2020). Sporadic white sponge nevus caused by a mutation in the keratin 4 gene. Oral and Maxillofacial Surgery Cases, 6(4), 100190.

Takashima, K., Fujii, S., Komatsuzaki, R., Komatsu, M., Takahashi, M., Kojima, T., ... & Yano, T. (2020). CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. International Journal of Oncology, 56(3), 835-847.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Zhang, J., Quan, J., Ren, Y., Chen, M., Yang, J., & Zhang, X. (2018). Keratin 4 regulates the development of human white sponge nevus. Journal of Oral Pathology & Medicine, 47(6), 598-605.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-KRT4 Recombinant Antibody (CBLY1-153)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare