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Mouse Anti-KRT4 Recombinant Antibody (CBFYM-1197) (CBMAB-M1354-FY)


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Summary

Host Animal
Mouse
Specificity
Guinea pig, Human, Mouse, Rat, Cattle, Goat, Frog, Pig
Clone
CBFYM-1197
Antibody Isotype
IgG1
Application
WB, IHC-P, IF, FC

Basic Information

Immunogen
A keratin-enriched preparation from cultured human A431
Specificity
Guinea pig, Human, Mouse, Rat, Cattle, Goat, Frog, Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.01% BSA
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Entrez Gene ID
Human3851
Rat315323
Mouse16682
Guinea pig100729006
Cattle527819
Goat102183210
Pig100157675
UniProt ID
HumanP19013
RatQ6IG00
MouseP07744
Guinea pigA0A286Y0S5
CattleA4IFP2
GoatA0A452G800
PigI3LQN8
Alternative Names
Keratin 4; CYK4; Keratin, Type II Cytoskeletal 4; Type-II Keratin Kb4; Cytokeratin 4; CK-4; K4
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Cellular Location
Cell surface
Cytosol
Intermediate filament
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 1 (WSN1):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
More Infomation

Li, X., Fang, J., Tao, X., Xia, J., Cheng, B., & Wang, Y. (2023). Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. PeerJ, 11, e14824.

Takan, I., Karakülah, G., Louka, A., & Pavlopoulou, A. (2023). “In the light of evolution:” keratins as exceptional tumor biomarkers. PeerJ, 11, e15099.

Hu, W. Y., Hu, D. P., Xie, L., Nonn, L., Lu, R., Abern, M., ... & Prins, G. S. (2021). Keratin profiling by single-cell RNA-sequencing identifies human prostate stem cell lineage hierarchy and cancer stem-like cells. International Journal of Molecular Sciences, 22(15), 8109.

Kanazawa, H., Kita, A., Ishida, N., Miyamoto, I., Kasamatsu, A., & Uzawa, K. (2020). Sporadic white sponge nevus caused by a mutation in the keratin 4 gene. Oral and Maxillofacial Surgery Cases, 6(4), 100190.

Takashima, K., Fujii, S., Komatsuzaki, R., Komatsu, M., Takahashi, M., Kojima, T., ... & Yano, T. (2020). CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. International Journal of Oncology, 56(3), 835-847.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Zhang, J., Quan, J., Ren, Y., Chen, M., Yang, J., & Zhang, X. (2018). Keratin 4 regulates the development of human white sponge nevus. Journal of Oral Pathology & Medicine, 47(6), 598-605.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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