LHB
LHB (Luteinizing Hormone Beta Polypeptide) is a Protein Coding gene. Diseases associated with LHB include Hypogonadotropic Hypogonadism 23 Without Anosmia and Tendinitis. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity. An important paralog of this gene is CGB7.
Full Name
LHB
Function
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Progesterone biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Progesterone biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Involvement in disease
Hypogonadotropic hypogonadism 23 without anosmia (HH23):
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
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Anti-LHB antibodies
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CompareTarget: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-288
Application*: IH
Target: LHB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-287
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-286
Application*: E, WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-285
Application*: E, R
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Horse
Clone: CBYJL-2525
Application*: E, WB
Target: LHB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP132
Application*: P
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: n.a
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: M94187
Application*: E, WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LHb/1214
Application*: F, P
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: LH210
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LH01
Application*: P
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: L1
Application*: WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1592
Application*: C, P
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B212M
Application*: E, WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9L458
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 9L457
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9F31
Application*: E, WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9008
Application*: E, IP, R
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9.F.500
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1591
Application*: E, R
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1589
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1588
Application*: IH
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1587
Application*: R
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5304
Application*: E, IP, R
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 402
Application*: IA
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1586
Application*: IH
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1584
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBYJL-1582
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBYJL-1574
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat
Clone: CBYJL-1573
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJL-1572
Application*: E, WB
Target: LHB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 10g200
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1571
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1569
Application*: E, IA Antibody Pairs
Target: LHB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 057-10036
Application*: E
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A901
Application*: FC, IF, IHC
Target: LHB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A900
Application*: FC, IF, IHC
Target: LHB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2611
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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