Mouse Anti-LHB Recombinant Antibody (A900) (CBMAB-AP4310LY)

The product is antibody recognizes LHB. The antibody A900 immunoassay techniques such as: FC, IF, IHC.
See all LHB antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

A900

Antibody Isotype

IgG1, κ

Application

FC, IF, IHC

Basic Information

Immunogen

Recombinant beta sub-unit of human LH

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

LHB

Entrez Gene ID

3972

UniProt ID

P01229

Alternative Names

CHORIONIC GONADOTROPIN, BETA POLYPEPTIDE 4 (CGB4), hLHB, Interstitial cell stimulating hormone beta chain, Leutropin, LH-B, LHB, LSH-B, LSH-beta, Luteinizing hormone beta polypeptide, Luteinizing hormone subunit beta, Lutropin beta chain, Lutropin subunit beta

Function

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Progesterone biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

Involvement in disease

Hypogonadotropic hypogonadism 23 without anosmia (HH23):
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.

References

Barnabas, R., Jadhav, S., Arya, S., Lila, A. R., Sarathi, V., Shah, G. R., ... & Bandgar, T. (2023). Luteinizing hormone β‐subunit deficiency: Report of a novel LHB likely pathogenic variant and a systematic review of the published literature. Clinical Endocrinology, 98(3), 383-393.

Moriyama, R., Iwamoto, K., Hagiwara, T., Yoshida, S., Kato, T., & Kato, Y. (2020). AMP-activated protein kinase activation reduces the transcriptional activity of the murine luteinizing hormone β-subunit gene. Journal of Reproduction and Development, 66(2), 97-104.

Essa, N., Osman, S., Jemaah, S., Hassan, M. A., & Eltayeb, R. (2020). Novel Mutations in Human Luteinizing Hormone Beta Subunit Related to Polycystic Ovary Syndrome among Sudanese Women. medRxiv, 2020-10.

Kalwar, Q., Chu, M., Ahmad, A. A., Ding, X., Wu, X., Bao, P., & Yan, P. (2019). Morphometric evaluation of spermatogenic cells and seminiferous tubules and exploration of luteinizing hormone beta polypeptide in testis of datong yak. Animals, 10(1), 66.

Yang, X., Ochin, H., Shu, L., Liu, J., Shen, J., Liu, J., ... & Cui, Y. (2018). Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism. Journal of assisted reproduction and genetics, 35, 913-919.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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