Mouse Anti-LHB Recombinant Antibody (n.a) (CBMAB-L1421-YJ)

Name: Mouse Anti-LHB Recombinant Antibody (n.a)
SKU: CBMAB-L1421-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

n.a

Application

ELISA

Immunogen

Human beta-Leutineizing Hormone (beta-LH).

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LHB

Introduction

LHB is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity. An important paralog of this gene is CGB7.

Entrez Gene ID

3972

UniProt ID

P01229

Alternative Names

CGB4; HH23; LSH-B; LSH-beta

Function

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Male gonad developmentManual Assertion Based On ExperimentTAS:ProtInc
Progesterone biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

Involvement in disease

Hypogonadotropic hypogonadism 23 without anosmia (HH23):
A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.

Barnabas, R., Jadhav, S., Arya, S., Lila, A. R., Sarathi, V., Shah, G. R., ... & Bandgar, T. (2023). Luteinizing hormone β‐subunit deficiency: Report of a novel LHB likely pathogenic variant and a systematic review of the published literature. Clinical Endocrinology, 98(3), 383-393.

Moriyama, R., Iwamoto, K., Hagiwara, T., Yoshida, S., Kato, T., & Kato, Y. (2020). AMP-activated protein kinase activation reduces the transcriptional activity of the murine luteinizing hormone β-subunit gene. Journal of Reproduction and Development, 66(2), 97-104.

Essa, N., Osman, S., Jemaah, S., Hassan, M. A., & Eltayeb, R. (2020). Novel Mutations in Human Luteinizing Hormone Beta Subunit Related to Polycystic Ovary Syndrome among Sudanese Women. medRxiv, 2020-10.

Kalwar, Q., Chu, M., Ahmad, A. A., Ding, X., Wu, X., Bao, P., & Yan, P. (2019). Morphometric evaluation of spermatogenic cells and seminiferous tubules and exploration of luteinizing hormone beta polypeptide in testis of datong yak. Animals, 10(1), 66.

Yang, X., Ochin, H., Shu, L., Liu, J., Shen, J., Liu, J., ... & Cui, Y. (2018). Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism. Journal of assisted reproduction and genetics, 35, 913-919.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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