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LMO1

LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted. [provided by RefSeq]

Full Name

LIM domain only 1 (rhombotin 1)

Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Biological Process

Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of T cell homeostatic proliferationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

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Anti-LMO1 antibodies

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Mouse Anti-LMO1 Recombinant Antibody (4C7) (CBMAB-A5014-LY)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4C7

Application*: WB, E

Mouse Anti-LMO1 Recombinant Antibody (CBYCL-391) (CBMAB-L0292-YC)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-391

Application*: IF, E, WB

Mouse Anti-LMO1 Recombinant Antibody (CBYCL-390) (CBMAB-L0291-YC)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-390

Application*: E, IF, WB

Mouse Anti-LMO1 Recombinant Antibody (CBYJL-1867) (CBMAB-L1852-YJ)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1867

Application*: WB, DB

Mouse Anti-LMO1 Recombinant Antibody (790C2a) (CBMAB-L1850-YJ)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 790C2a

Application*: DB, IC

Mouse Anti-LMO1 Recombinant Antibody (CBYJL-1865) (CBMAB-L1849-YJ)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1865

Application*: E, IF, WB

Mouse Anti-LMO1 Recombinant Antibody (CBYJL-1864) (CBMAB-L1848-YJ)

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Target: LMO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1864

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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