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Mouse Anti-LMO1 Recombinant Antibody (CBYJL-1865) (CBMAB-L1849-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lim Domain Only 1 (LMO1). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all LMO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1865
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIM domain only 1 (rhombotin 1)
Introduction
LMO1 is a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may function in protein interactions; thus LMO1 may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been found.
Entrez Gene ID
4004
UniProt ID
P25800
Alternative Names
TTG1; RBTN1; RHOM1
Function
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Biological Process
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of T cell homeostatic proliferationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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