Mouse Anti-LMO1 Recombinant Antibody (4C7) (CBMAB-A5014-LY)

Name: Mouse Anti-LMO1 Recombinant Antibody (4C7)
SKU: CBMAB-A5014-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4C7

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

LMO1 (NP_002306, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

LIM domain only 1 (rhombotin 1)

Introduction

LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted. [provided by RefSeq]

Entrez Gene ID

4004

UniProt ID

P25800

Alternative Names

MGC116692; RBTN1; RHOM1; TTG1

Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Biological Process

Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of T cell homeostatic proliferationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

More Infomation

References

Zhao, G. F., Du, L. Q., Zhang, L., & Jia, Y. C. (2021). LIM domain only 1: an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types. Chinese Medical Journal, 134(09), 1017-1030.

Yu, L., Liu, X. Q., Chen, Y. H., Chen, X., & Nie, M. H. (2020). Study on expression of LIM domain only protein 1 in SD rat oral buccal mucosa carcinogenesis induced by 4-nitro-quinoline N-oxide. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 38(2), 133-138.

Saeki, N., Saito, A., Sugaya, Y., Amemiya, M., Ono, H., Komatsuzaki, R., ... & Sasaki, H. (2018). Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by LMO1 in neuroblastoma. Cancer Genomics & Proteomics, 15(3), 165-174.

Du, L., Zhao, Z., Suraokar, M., Shelton, S. S., Ma, X., Hsiao, T. H., ... & Pertsemlidis, A. (2018). LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget, 9(51), 29601.

He, L., Zhu, J., Han, F., Tang, Y., Zhou, C., Dai, J., ... & Wu, H. (2018). LMO1 gene polymorphisms reduce neuroblastoma risk in eastern Chinese children: a three-center case-control study. Frontiers in Oncology, 8, 468.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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