LMP-1

Epstein-Barr Virus latent membrane protein 1 (EBV LMP-1) is one of few proteins expressed during the lysogenic or latent infection cycle of Epstein-Barr Virus, a member of the herpes family also known as Human Herpesvirus 4 (HHV-4). LMP-1 is a protooncogene that is expressed in most EBV-associated human malignancies. Anti-EBV LMP-1 is useful for detecting Hodgkin and Reed-Sternberg cells in classical Hodgkin's lymphoma.

Full Name

LAMP family protein lmp-1

Function

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2.

Biological Process

Induction by virus of host NF-kappaB cascadeIEA:UniProtKB-KW
Suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activityIEA:UniProtKB-KW
Suppression by virus of host TRAF activityIEA:UniProtKB-KW
Suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW
Transformation of host cell by virusIEA:InterPro

Cellular Location

Host cell membrane

Topology

Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-51
Helical: 52-72
Cytoplasmic: 73-75
Helical: 76-96
Extracellular: 97-106
Helical: 107-127
Cytoplasmic: 128-139
Helical: 140-160
Extracellular: 161-163
Helical: 164-184
Cytoplasmic: 185-386

PTM

Ubiquitinated on the N-terminus.