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LRRC32

This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
Full Name
leucine rich repeat containing 32
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742).
Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742).
Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).
Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619).
Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).
Biological Process
Negative regulation of activated T cell proliferationIEA:Ensembl
Negative regulation of cytokine productionIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Regulation of transforming growth factor beta activationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transforming growth factor beta3 activationIEA:Ensembl
Secondary palate developmentISS:UniProtKB
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Cell surface
Involvement in disease
Cleft palate, proliferative retinopathy, and developmental delay (CPPRDD):
An autosomal recessive disorder characterized by mild to severe intellectual disability with delayed or absent speech, hypotonia, cleft palate, proliferative retinopathy, and combined sensorineural and conductive hearing loss. Brain imaging shows ventriculomegaly, widened subarachnoid spaces, partial agenesis of the corpus callosum, hypoplastic cerebellar vermis, and Dandy Walker malformation.
Topology
Extracellular: 20-627
Helical: 628-648
Cytoplasmic: 649-662
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Anti-LRRC32 antibodies

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Mouse Anti-LRRC32 Recombinant Antibody (CBYCL-480) (CBMAB-L0381-YC)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-480
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (CBYCL-479) (CBMAB-L0380-YC)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYCL-479
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (CBYCL-478) (CBMAB-L0379-YC)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYCL-478
Application*: E, IP, WB
Datasheet SDS

Rat Anti-Lrrc32 Recombinant Antibody (CBYJL-2498) (CBMAB-L2890-YJ)

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Target: Lrrc32
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2498
Application*: FC
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (PLATO1) (CBMAB-L2111-YJ)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: PLATO1
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (GARP5) (CBMAB-L2110-YJ)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GARP5
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (ANC8C9) (CBMAB-L2109-YJ)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: ANC8C9
Application*: E, F
Datasheet SDS

Rat Anti-LRRC32 Recombinant Antibody (CBYJL-2009) (CBMAB-L2108-YJ)

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Target: LRRC32
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2009
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (CBLG1-2382) (CBMAB-G6363-LY)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBLG1-2382
Application*: F
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (CBLG1-2381) (CBMAB-G6362-LY)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2381
Application*: WB
Datasheet SDS

Mouse Anti-LRRC32 Recombinant Antibody (7B11) (CBMAB-G6360-LY)

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Target: LRRC32
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 7B11
Application*: F
Datasheet SDS

Rat Anti-LRRC32 Recombinant Antibody (YGIC86) (CBMAB-G1141-LY)

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Target: LRRC32
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: YGIC86
Application*: F
Datasheet SDS

Human Anti-LRRC32 Recombinant Antibody (REA166) (CBMAB-G1140-LY)

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Target: LRRC32
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: REA166
Application*: F
Datasheet SDS

Human Anti-LRRC32 Recombinant Antibody (REA139) (CBMAB-G1139-LY)

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Target: LRRC32
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: REA139
Application*: F
Datasheet SDS

Rat Anti-LRRC32 Recombinant Antibody (G14D9) (CBMAB-G1137-LY)

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Target: LRRC32
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: G14D9
Application*: F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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