M. tuberculosis hspX

Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection.

Full Name

alpha-crystallin

Function

Biological Process

Cellular response to hypoxiaManual Assertion Based On ExperimentIEP:MTBBASE
Cellular response to starvationManual Assertion Based On ExperimentIEP:MTBBASE
Negative regulation of growthManual Assertion Based On ExperimentIMP:MTBBASE
Protein autophosphorylationManual Assertion Based On ExperimentIDA:MTBBASE
Protein foldingManual Assertion Based On ExperimentIDA:MTBBASE
Response to heatManual Assertion Based On ExperimentIDA:MTBBASE
Response to hostManual Assertion Based On ExperimentIEP:MTBBASE
Response to host immune responseManual Assertion Based On ExperimentIEP:MTBBASE
Response to hypoxiaManual Assertion Based On ExperimentIDA:MTBBASE
Response to iron ionManual Assertion Based On ExperimentIEP:MTBBASE
Response to nitrosative stressManual Assertion Based On ExperimentIEP:MTBBASE

Cellular Location

Cytoplasm
Secreted, cell wall
Probably the external side of the cell wall; the protein is very abundant in older organisms and surface coating could be the result of autolysis of older organisms.

PTM

Multiple forms of this protein exist in 2D-gels. The differences between them has not been examined.