MCRS1

MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include Herpes Simplex and Pigmented Basal Cell Carcinoma. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

Full Name

Microspherule Protein 1

Function

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183).

As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852).

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100).

Binds to G-quadruplex structures in mRNA (PubMed:16571602).

Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602).

Biological Process

Cellular protein modification process Source: ProtInc
Chromatin remodeling Source: ComplexPortal
DNA recombination Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Histone H4-K16 acetylation Source: UniProtKB
Histone H4-K5 acetylation Source: UniProtKB
Histone H4-K8 acetylation Source: UniProtKB
Negative regulation of telomerase activity Source: BHF-UCL
Negative regulation of telomere maintenance via telomere lengthening Source: BHF-UCL
Nucleosome mobilization Source: ComplexPortal
Positive regulation of DNA repair Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: ComplexPortal
Positive regulation of protein localization to nucleolus Source: UniProtKB
Positive regulation of telomere maintenance in response to DNA damage Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of cell cycle Source: ComplexPortal
Regulation of chromosome organization Source: ComplexPortal
Regulation of DNA replication Source: ComplexPortal
Regulation of DNA strand elongation Source: ComplexPortal
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Regulation of embryonic development Source: Ensembl
Telomere maintenance Source: Ensembl

Cellular Location

Nucleus
Nucleolus
Cytoplasm
Note: In microspherules in the nucleolus.