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Mouse Anti-MCRS1 Recombinant Antibody (CBFYM-1925) (CBMAB-M2099-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYM-1925
Application
WB, IP, IF, ELISA
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Microspherule Protein 1
Introduction
MCRS1 is a Protein Coding gene. Diseases associated with MCRS1 include Herpes Simplex and Pigmented Basal Cell Carcinoma. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology annotations related to this gene include histone acetyltransferase activity and histone acetyltransferase activity.
Entrez Gene ID
10445
UniProt ID
Q96EZ8
Alternative Names
Microspherule Protein 1; Cell Cycle-Regulated Factor P78; 58 KDa Microspherule Protein; INO80 Complex Subunit Q; INO80 Complex Subunit J; INO80Q
Function
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183).

As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852).

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100).

Binds to G-quadruplex structures in mRNA (PubMed:16571602).

Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602).
Biological Process
Cellular protein modification process Source: ProtInc
Chromatin remodeling Source: ComplexPortal
DNA recombination Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Histone H4-K16 acetylation Source: UniProtKB
Histone H4-K5 acetylation Source: UniProtKB
Histone H4-K8 acetylation Source: UniProtKB
Negative regulation of telomerase activity Source: BHF-UCL
Negative regulation of telomere maintenance via telomere lengthening Source: BHF-UCL
Nucleosome mobilization Source: ComplexPortal
Positive regulation of DNA repair Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: ComplexPortal
Positive regulation of protein localization to nucleolus Source: UniProtKB
Positive regulation of telomere maintenance in response to DNA damage Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of cell cycle Source: ComplexPortal
Regulation of chromosome organization Source: ComplexPortal
Regulation of DNA replication Source: ComplexPortal
Regulation of DNA strand elongation Source: ComplexPortal
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Regulation of embryonic development Source: Ensembl
Telomere maintenance Source: Ensembl
Cellular Location
Nucleus
Nucleolus
Cytoplasm
Note: In microspherules in the nucleolus.

Laguillo-Diego, A., Kiewisz, R., Martí-Gómez, C., Baum, D., Müller-Reichert, T., & Vernos, I. (2023). MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles. Molecular Biology of the Cell, 34(1), ar1.

Huang, C. J., Lyu, X., & Kang, J. (2023). The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development. Cell Cycle, 22(6), 619-632.

Ju, J. Q., Pan, Z. N., Zhang, K. H., Ji, Y. M., Liu, J. C., & Sun, S. C. (2023). Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis. EMBO reports, 24(5), e56273.

Keer, S., Cousin, H., Jourdeuil, K., Neilson, K. M., Tavares, A. L., Alfandari, D., & Moody, S. A. (2022). Mcrs1 is required for branchial arch and cranial cartilage development. Developmental biology, 489, 62-75.

Wang, L. H., Chang, C. C., Cheng, C. Y., Liang, Y. J., Pei, D., Sun, J. T., & Chen, Y. L. (2022). MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer. Diagnostics, 12(6), 1502.

Neilson, K. M., Keer, S., Bousquet, N., Macrorie, O., Majumdar, H. D., Kenyon, K. L., ... & Moody, S. A. (2020). Mcrs1 interacts with Six1 to influence early craniofacial and otic development. Developmental biology, 467(1-2), 39-50.

Cui, W., Cheong, A., Wang, Y., Tsuchida, Y., Liu, Y., Tremblay, K. D., & Mager, J. (2020). MCRS1 is essential for epiblast development during early mouse embryogenesis. Reproduction, 159(1), 1-13.

Wang, H., Ou, J., Jian, Z., & Ou, Y. (2019). miR‐186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1‐mediated Wnt/β‐catenin signaling. Journal of Cellular Physiology, 234(12), 23135-23145.

Yang, H., Zhang, F., Huang, C. J., Liao, J., Han, Y., Hao, P., ... & Kang, J. (2019). Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment. Molecular biology of the cell, 30(9), 1060-1068.

Wang, X. M., Li, Q. Y., Ren, L. L., Liu, Y. M., Wang, T. S., Mu, T. C., ... & Xiao, J. Y. (2019). Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase. Cellular Signalling, 59, 171-181.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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