NAALADL1
NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).
Full Name
N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1
Function
Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612).
Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612).
Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612).
Biological Process
Peptide catabolic process Source: UniProtKB
Cellular Location
Plasma membrane
Apical cell membrane
Note: Ileal brush border membrane.
Apical cell membrane
Note: Ileal brush border membrane.
Topology
Cytoplasmic: 1-6
Helical: 7-28
Extracellular: 29-740
Helical: 7-28
Extracellular: 29-740
PTM
N-glycosylated.
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Anti-NAALADL1 antibodies
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Target: NAALADL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3C5G10E8
Application*: E
Target: NAALADL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1153
Application*: WB, E
Target: NAALADL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJN-1151
Application*: P
Target: NAALADL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJN-1150
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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