Sign in or Register

NEK4

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.
Full Name
NIMA (never in mitosis gene a)-related kinase 4
Function
Protein kinase that seems to act exclusively upon threonine residues (By similarity).

Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
Biological Process
Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: CACAO
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of response to DNA damage stimulus Source: CACAO
Cellular Location
Cytoplasm
Other locations
cilium
View more

Anti-NEK4 antibodies

+ Filters
Loading...

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-1317) (CBMAB-N1930-WJ)

Go to compareCompare
Target: NEK4
Host: Mouse
Specificity: Human
Clone: CBWJN-1317
Application*: WB
Datasheet SDS

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-0314) (CBMAB-N0246-WJ)

Go to compareCompare
Target: NEK4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0314
Application*: DB, WB
Datasheet SDS

Mouse Anti-NEK4 Recombinant Antibody (1B8) (CBMAB-N0245-WJ)

Go to compareCompare
Target: NEK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B8
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry