NEK4

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.

Full Name

NIMA (never in mitosis gene a)-related kinase 4

Function

Protein kinase that seems to act exclusively upon threonine residues (By similarity).

Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Biological Process

Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: CACAO
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of response to DNA damage stimulus Source: CACAO

Cellular Location

Cytoplasm
Other locations
cilium

Anti-NEK4 antibodies

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-1317) (CBMAB-N1930-WJ)

Datasheet

SDS

Target: NEK4

Host: Mouse

Specificity: Human

Clone: CBWJN-1317

Application*: WB

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-0314) (CBMAB-N0246-WJ)

Datasheet

SDS

Target: NEK4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0314

Application*: DB, WB

Mouse Anti-NEK4 Recombinant Antibody (1B8) (CBMAB-N0245-WJ)

Datasheet

SDS

Target: NEK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1B8

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)