loading...

NEK4

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.

Full Name

NIMA (never in mitosis gene a)-related kinase 4

Function

Protein kinase that seems to act exclusively upon threonine residues (By similarity).

Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Biological Process

Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: CACAO
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of response to DNA damage stimulus Source: CACAO

Cellular Location

Cytoplasm
Other locations
cilium

View more

Anti-NEK4 antibodies

+ Filters

Loading...

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-1317) (CBMAB-N1930-WJ)

Compare

Target: NEK4

Host: Mouse

Specificity: Human

Clone: CBWJN-1317

Application*: WB

Mouse Anti-NEK4 Recombinant Antibody (CBWJN-0314) (CBMAB-N0246-WJ)

Compare

Target: NEK4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0314

Application*: DB, WB

Mouse Anti-NEK4 Recombinant Antibody (1B8) (CBMAB-N0245-WJ)

Compare

Target: NEK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1B8

Application*: E, WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry