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Mouse Anti-NEK4 Recombinant Antibody (1B8) (CBMAB-N0245-WJ)

This product is a Mouse antibody that recognizes NEK4. The antibody 1B8 can be used for immunoassay techniques such as: ELISA, WB.
See all NEK4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NIMA (never in mitosis gene a)-related kinase 4
Introduction
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Entrez Gene ID
6787
UniProt ID
P51957
Alternative Names
NIMA Related Kinase 4; NIMA (Never In Mitosis Gene A)-Related Kinase 4; Serine/Threonine-Protein Kinase NRK2; Never In Mitosis A-Related Kinase 4; Serine/Threonine Protein Kinase-2; NimA-Related Protein Kinase 4; Serine/Threonine Kinase 2; EC 2.7.11.1;
Function
Protein kinase that seems to act exclusively upon threonine residues (By similarity).

Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
Biological Process
Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: CACAO
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of response to DNA damage stimulus Source: CACAO
Cellular Location
Cytoplasm
Other locations
cilium
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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