Mouse Anti-NEK4 Recombinant Antibody (CBWJN-0314) (CBMAB-N0246-WJ)

Name: Mouse Anti-NEK4 Recombinant Antibody (CBWJN-0314)
SKU: CBMAB-N0246-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJN-0314

Application

Dot, WB

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NIMA (never in mitosis gene a)-related kinase 4

Introduction

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

Entrez Gene ID

6787

UniProt ID

P51957

Alternative Names

NIMA Related Kinase 4; NIMA (Never In Mitosis Gene A)-Related Kinase 4; Serine/Threonine-Protein Kinase NRK2; Never In Mitosis A-Related Kinase 4; Serine/Threonine Protein Kinase-2; NimA-Related Protein Kinase 4; Serine/Threonine Kinase 2; EC 2.7.11.1;

Function

Protein kinase that seems to act exclusively upon threonine residues (By similarity).

Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Biological Process

Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: CACAO
Protein phosphorylation Source: UniProtKB
Regulation of cellular senescence Source: UniProtKB
Regulation of response to DNA damage stimulus Source: CACAO

Cellular Location

Cytoplasm
Other locations
cilium

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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