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NSF

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

Full Name

N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

Biological Process

ExocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIBA:GO_Central
Intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Intracellular protein transportManual Assertion Based On ExperimentIMP:CACAO
Plasma membrane fusionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportIEA:Ensembl
Regulation of exocytosisISS:ParkinsonsUK-UCL
SNARE complex disassemblyISS:ParkinsonsUK-UCL
Vesicle-mediated transportISS:ParkinsonsUK-UCL

Cellular Location

Cytoplasm

Involvement in disease

Developmental and epileptic encephalopathy 96 (DEE96):
A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE96 is an autosomal dominant form characterized by onset of seizures in the first days or weeks of life. Affected infants also have hypotonia with respiratory insufficiency that may result in premature death.

PTM

Phosphorylation at Ser-569 interferes with homohexamerization.

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Anti-NSF antibodies

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Mouse Anti-NSF Monoclonal Antibody (NSF-1) (CBMAB-1432-YC)

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Target: NSF

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Chicken, Cattle

Clone: NSF-1

Application*: F, IC, IF, P, IP, WB

Mouse Anti-NSF Recombinant Antibody (CBXS-0051) (CBMAB-S3052-CQ)

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Target: NSF

Host: Mouse

Specificity: Human

Clone: CBXS-0051

Application*: WB, IC, P, C, E

Mouse Anti-NSF Recombinant Antibody (CBWJN-0752) (CBMAB-N3661-WJ)

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Target: NSF

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Chicken, Human, Mouse, Rat

Clone: CBWJN-0752

Application*: E, IP, WB

Mouse Anti-NSF Recombinant Antibody (G-7) (CBMAB-N3660-WJ)

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Target: NSF

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: G-7

Application*: WB, IP, IF, E

Rabbit Anti-NSF Recombinant Antibody (D31C7) (CBMAB-N3659-WJ)

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Target: NSF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D31C7

Application*: WB, IP, IF

Mouse Anti-NSF Recombinant Antibody (B-9) (CBMAB-N3658-WJ)

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Target: NSF

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: B-9

Application*: WB, IP, IF, E

Mouse Anti-NSF Recombinant Antibody (A-3) (CBMAB-N3657-WJ)

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Target: NSF

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: A-3

Application*: WB, IP, IF, E

Mouse Anti-NSF Recombinant Antibody (CBWJN-0475) (CBMAB-N3656-WJ)

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Target: NSF

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Chicken, Dog, Mouse, Rat

Clone: CBWJN-0475

Application*: WB, BI, IF

Mouse Anti-NSF Recombinant Antibody (CBWJN-0519) (CBMAB-N0542-WJ)

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Target: NSF

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat, Sheep, Rabbit, Pig, Monkey, Hamster, Dog, Chicken, Cattle

Clone: CBWJN-0519

Application*: P, WB

Mouse Anti-NSF Recombinant Antibody (4E164) (CBMAB-N0541-WJ)

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Target: NSF

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Cattle, Dog, Chicken, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep

Clone: 4E164

Application*: IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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